Complement Component C3, C4, CH50

Complement Component C3, C4, CH50

Test Code

37859
86160 (x2), 86162
37859
86160 (x2), 86162
Not offered in Quest Nichols Institute - Chantilly, VA | Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Complement Component C3, C4, CH50 - This panel may be useful in evaluating patients with clinical suspicion of systemic lupus erythematosus (SLE). This panel includes measurements of complement component 3 (C3), complement component 4 (C4), and total hemolytic complement (CH50).

Low levels of C3 and/or C4 are included in the 2019 SLE classification criteria from EULAR (European League Against Rheumatism/American College of Rheumatology) [1], whereas the 2012 Systemic Lupus International Collaborating Clinics classification criteria for SLE include low levels of C3, C4, or CH50 [2]. Without SLE diagnostic criteria in place, ...

Test Resources

Clinical Focus

Autoimmune Rheumatic and Related Diseases

Test Details

Patient Preparation

Overnight fasting is preferred

Methodology

Immunoturbidimetric • Liposome

Reference Range(s)

See individual tests

LOINC® Codes, Performing Laboratory

Service Area must be determined
Overnight fasting is preferred

Methodology

Immunoturbidimetric • Liposome

Reference Range(s)

See individual tests
Service Area must be determined

Preferred Specimen(s)

3 mL frozen serum

Minimum Volume

1.5 mL

Collection Instructions

Draw sample without anticoagulant, allow to clot. Separate serum into a transport tube and freeze sample within 1 hour of the draw. Avoid hemolysis.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: Unacceptable
    Refrigerated: Unacceptable
    Frozen: 7 days

Reject Criteria

Gross hemolysis • Lipemia • Received room temperature • Received refrigerated • Received thawed

Setup Schedule

Service Area must be determined
3 mL frozen serum
1.5 mL
Draw sample without anticoagulant, allow to clot. Separate serum into a transport tube and freeze sample within 1 hour of the draw. Avoid hemolysis.
Transport tube
Frozen
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 7 days
Gross hemolysis • Lipemia • Received room temperature • Received refrigerated • Received thawed
Service Area must be determined
Not offered in Quest Nichols Institute - Chantilly, VA | Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.

Customize the test information for your Service Area