Creatine Kinase Isoenzymes (CK Isoenzymes) without Total CK
Test Code
Clinical Significance
Creatine Kinase Isoenzymes (CK Isoenzymes) without Total CK - This test measures creatine kinase (CK) isoenzymes and may be useful in assessing disorders associated with muscle damage. Fractions of CK isoenzymes relative to total CK levels are reported.
Creatine kinase (CK) is a dimeric enzyme composed of either 2 B subunits (CK-BB), 2 M subunits (CK-MM), or an M and a B subunit (CK-MB). CK-MM is the primary isoenzyme found in the skeletal muscle and heart tissue. CK-BB is mainly found in the brain and smooth muscle of gastrointestinal tract and urinary bladder. CK-MB is mainly found in the heart with a small amount in skeletal muscle [1].
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Test Resources
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Test Details
Methodology
Reference Range(s)
| CK-BB | None Detected |
| CK-MB | <5 % of total |
| CK-MM | 95-100 % of total |
Alternative Name(s)
Preferred Specimen(s)
2 mL frozen serum
Minimum Volume
1 mL
Collection Instructions
Allow blood to clot at room temperature for 30 minutes. Centrifuge immediately to separate the serum from cells and pour serum into a plastic transport tube. If CK and CK isoenzymes are ordered together, specimen must be submitted frozen.
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
- Room temperature: Unacceptable
- Refrigerated: 48 hours
- Frozen: 14 days
Reject Criteria
Hemolysis • Received thawed
Setup Schedule
Refrigerated: 48 hours
Frozen: 14 days