Pre-biologic/biosimilar Screen Panel, HCV/HBV with Reflexes and QFT 1 Tube
Test Code
Clinical Significance
Pre-biologic/biosimilar Screen Panel, HCV/HBV with Reflexes and QFT 1 Tube - For patients diagnosed with any of a number of chronic autoimmune disorders (such as rheumatoid arthritis, plaque psoriasis, IBD and others), this panel combines screening for HCV, HBV and latent TB, all of which are required before initiating therapy with biologics and/or biosimilars. It is important to identify whether latent infections are present as they can rapidly manifest themselves in an immunosuppressed patient.
Test Resources
Test FAQ
QuantiFERON®-TB Gold PlusTest Details
QuantiFERON®-TB Gold Plus, 1 Tube
Hepatitis B Surface Antigen with Reflex Confirmation
Hepatitis B Surface Antibody Immunity, Quantitative
Hepatitis B Core Antibody, Total, with Reflex to IgM
Hepatitis C Antibody with Reflex to HCV RNA,PCR w/Reflex to Genotype, LiPA
Hepatitis B Surface Antigen: Reactive samples will be confirmed based on the manufacturer's FDA approved recommendations at an additional charge (CPT code(s): 87341).
If Hepatitis B Core Antibody Total is reactive, then Hepatitis B Core IgM Antibody will be performed at an additional charge (CPT code(s): 86705).
If Hepatitis C Antibody is reactive or borderline, then Hepatitis C Viral RNA, Quantitative, Real-Time PCR will be performed at an additional charge (CPT code(s): 87522).
If Hepatitis C Viral RNA, Quantitative, Real-Time PCR is ≥2000 IU/mL, then Hepatitis C Virus RNA Genotype will be performed at an additional charge (CPT code(s): 87902).
Methodology
Reference Range(s)
Alternative Name(s)
Preferred Specimen(s)
6 mL whole blood collected in a no-gel lithium heparin (green-top) tube and
2.5 mL serum collected in each of two separate serum separator tubes (SST) and
2.5 mL serum
Minimum Volume
6 mL whole blood • 2.5 mL serum in each of two separate serum separator tubes (SST) • 2.5 mL serum
Collection Instructions
Collect 6 mL of blood by venipuncture into a lithium heparin (green-top) tube. Hold tube at room temperature (17-25° C.) for between 15 minutes and 3 hours after blood collection. Refrigerate at 2-8° C.
Note: The Centers for Disease Control and Prevention (CDC) has provided guidance on clinical considerations for tuberculosis (TB) testing such as QuantiFERON®-TB Gold Plus in conjunction with COVID-19 mRNA vaccines. Please refer to the QuantiFERON®-TB Gold Plus FAQ link (https://education.questdiagnostics.com/faq/FAQ204) for more detailed information on the latest CDC guidelines regarding TB testing and COVID-19 vaccines.
Dietary supplements containing biotin may interfere in assays and may skew analyte results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Transport Container
See Preferred Specimen(s)
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- See individual tests
Reject Criteria
See individual tests
Setup Schedule
2.5 mL serum collected in each of two separate serum separator tubes (SST) and
2.5 mL serum
Collect 6 mL of blood by venipuncture into a lithium heparin (green-top) tube. Hold tube at room temperature (17-25° C.) for between 15 minutes and 3 hours after blood collection. Refrigerate at 2-8° C.
Note: The Centers for Disease Control and Prevention (CDC) has provided guidance on clinical considerations for tuberculosis (TB) testing such as QuantiFERON®-TB Gold Plus in conjunction with COVID-19 mRNA vaccines. Please refer to the QuantiFERON®-TB Gold Plus FAQ link (https://education.questdiagnostics.com/faq/FAQ204) for more detailed information on the latest CDC guidelines regarding TB testing and COVID-19 vaccines.
Dietary supplements containing biotin may interfere in assays and may skew analyte results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.