Cortisone, 24-Hour Urine

Test code

37554

CPT code(s)*

82542, 82570

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide Service area information to confirm Test Code for the lab that services your account or to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical significance

Cortisone, 24-Hour Urine - This test, when used in conjunction with the measurement of 24-hour urine cortisol, may help in the diagnosis of apparent mineralocorticoid excess (AME) syndrome [1].Cortisone is an inactive metabolite of cortisol converted by 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) in the kidney. In patients with AME syndrome, deficiency of 11-beta-HSD2 impairs the deactivation of cortisol to cortisone. Consequently, accumulated cortisol activates mineralocorticoid receptors and leads to clinical manifestations resembling primary aldosteronism. Patients with AME typically present with low-renin hypertension, hypokalemia, and metabolic…

Test resources

None found for this test
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Details

Test details

Includes

Creatinine

CPT code 81050 may be added at an additional charge for volume measurement

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Specimen requirements
Patient preparation	None Specified
Preferred specimen(s)	10 mL urine
Alternative specimen(s)	Random urine • Random clean catch urine • Catheterized urine • First void clean catch urine • Urine with no preservative
Minimum volume	2.1 mL
Collection instructions	Collect urine with 10 grams of boric acid or keep urine refrigerated during collection if preservative is not used. Record 24-hour urine volume on test requisition and urine vial. Note: Reference ranges do not apply to random urine samples.
Transport container	Plastic urine container
Transport temperature	Refrigerated (cold packs)
Specimen stability	Room temperature: 14 days Refrigerated: 21 days Frozen: 90 days

Reference range(s)

Reference Range(s)

Cortisone, 24-Hour Urine

Adults

23-195 mcg/24 h

Creatinine, 24-Hour Urine

<3 Years	Not established
3-8 Years	0.10-0.80 g/24 hours
9-12 Years	0.20-1.40 g/24 hours
13-17 Years	0.40-1.90 g/24 hours
>17 Years	0.50-2.15 g/24 hours

LOINC® codes

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Service Area Information

Performing lab & setup schedule

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Service Area Information

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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