ANA Multiplex, Panel 1 with Reflexes

ANA Multiplex, Panel 1 with Reflexes

Test Code

37521
86038, 86235 (x5), 86255, 86431
37521
86038, 86235 (x5), 86255, 86431
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

ANA Multiplex, Panel 1 with Reflexes - This panel can be helpful in the diagnosis of autoimmune rheumatic diseases, including systemic lupus erythematosus, systemic sclerosis, Sjogren syndrome, mixed connective tissue disease, and rheumatoid arthritis. All specimens are screened for antinuclear antibodies (ANAs) with multiplex immunoassay. This approach simultaneously detects antibodies to dsDNA, chromatin, ribosomal protein, SSA, SSB, Smith (Sm), Sm/RNP, RNP, Scl-70, Jo-1, and centromere B. A positive result indicates the presence of at least 1 of these antibodies; a negative result indicates that none of the component antibodies were ...

Test Resources

Clinical Focus

Autoimmune Rheumatic and Related Diseases

Test Details

Includes

  • ANA Screen, Immunoassay with Reflex to Titer and Pattern
    Rheumatoid Factor
    DNA (ds) Antibody, Crithidia IFA with Reflex to Titer
    Sm Antibody
    Sm/RNP Antibody
    Scleroderma Antibody (Scl-70)
    Sjogren's Antibodies (SS-A, SS-B)

    If the ANA Screen, Immunoassay is positive, then ANA titer and pattern will be performed at an additional charge (CPT code(s): 86039).
    If the DNA (ds) Antibody Screen is positive, then DNA (ds) Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

Patient Preparation

Overnight fasting is preferred

Methodology

See individual tests

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined
ANA Screen, Immunoassay with Reflex to Titer and Pattern
Rheumatoid Factor
DNA (ds) Antibody, Crithidia IFA with Reflex to Titer
Sm Antibody
Sm/RNP Antibody
Scleroderma Antibody (Scl-70)
Sjogren's Antibodies (SS-A, SS-B)

If the ANA Screen, Immunoassay is positive, then ANA titer and pattern will be performed at an additional charge (CPT code(s): 86039).
If the DNA (ds) Antibody Screen is positive, then DNA (ds) Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
Overnight fasting is preferred

Methodology

See individual tests

Reference Range(s)

See Laboratory Report
Service Area must be determined

Preferred Specimen(s)

3 mL serum

Minimum Volume

1.5 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 4 days
  • Refrigerated: 7 days
  • Frozen: 30 days

Reject Criteria

Gross hemolysis • Grossly lipemic

Setup Schedule

Service Area must be determined
3 mL serum
1.5 mL
Transport tube

Room temperature

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days
Gross hemolysis • Grossly lipemic
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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