Hu Antibody Screen with Reflex to Titer and Western Blot
Test Code
37053
86255
Clinical Significance
Hu Antibody Screen with Reflex to Titer and Western Blot - Paraneoplastic Syndrome involves non-metastatic systemic effects that accompany malignant disease. Antineuronal Nuclear Antibody (Anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Anti-Hu is associated with subacute syndrome of encephalomyeloradiculopathy, sensory neuropathy, and autoimmune neuropathy, predominantly affecting the gastrointestinal tract.
Test Resources
Test Details
If Hu Antibody Screen, IFA is positive, then Hu Antibody, WB will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB is positive, then Hu Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
If Hu Antibody, WB is positive, then Hu Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
Overnight fasting is preferred
Methodology
Immunofluorescence Assay (IFA) • Western Blot (WB)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range(s)
| Hu Ab Screen, IFA | Negative |
| Hu Ab, WB | Negative |
| Hu Ab Titer | <1:40 |
Alternative Name(s)
Neuronal Nuclear (Hu) Antibody
Preferred Specimen(s)
0.5 mL serum
Minimum Volume
0.2 mL
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: 21 days
Setup Schedule
0.5 mL serum
0.2 mL
Transport tube
Room temperature
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days
Refrigerated: 14 days
Frozen: 21 days