Myelin Oligodendrocyte Glycoprotein(MOG)Antibody with Reflex to Titer,Serum

Test Code

36952

CPT Code(s)

86362

Test Code

36952

CPT Code(s)

86362

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Myelin Oligodendrocyte Glycoprotein(MOG)Antibody with Reflex to Titer,Serum - Neuromyelitis optica (NMO) is an inflammatory disorder predominantly affecting the optic nerves and spinal cord. Limited forms of disease including isolated optic neuritis, brainstem encephalitis and longitudinal extensive transverse myelitis (LETM) or acute disseminated encephalomyelitis (ADEM) have been referred to as NMO spectrum disorder (NMOSD). The majority of individuals with NMO and many with NMOSD have antibodies against aquaporin 4 (AQP4). MOG antibodies have been reported without AQP4 antibodies in individuals with NMO and other non-multiple sclerosis demyelinating diseases. The presence ...

Test Resources

Clinical Focus

Neuromyelitis Optica Spectrum Disorders: Laboratory Support of Diagnosis and Management

Test Details

Includes

If the MOG Antibody screen is positive, then a semi-quantitative titer will be performed at an additional charge (CPT code(s): 86362).

Methodology

Cell-based Immunofluorescence Assay

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

MOG Ab CBA, Serum	Negative
MOG Ab Titer, Serum	<1:10 titer

Alternative Name(s)

Transverse Myelitis Antibody,MOG-IgG,Myelin oligodendrocyte glycoprotein,NMO Spectrum Disorder,LETM antibody,Optic Neuritis Antibody,ADEM antibody,NMOSD

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

If the MOG Antibody screen is positive, then a semi-quantitative titer will be performed at an additional charge (CPT code(s): 86362).

Methodology

Cell-based Immunofluorescence Assay

Assay Category

Reference Range(s)

MOG Ab CBA, Serum	Negative
MOG Ab Titer, Serum	<1:10 titer

Alternative Name(s)

Transverse Myelitis Antibody,MOG-IgG,Myelin oligodendrocyte glycoprotein,NMO Spectrum Disorder,LETM antibody,Optic Neuritis Antibody,ADEM antibody,NMOSD

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

2 mL serum collected in red-top tube (no gel)

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria

Visible particulate matter • Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

2 mL serum collected in red-top tube (no gel)

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria

Visible particulate matter • Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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