Islet Cell Antibody Screen with Reflex to Titer

Test Code

36741

CPT Code(s)

86341

Test Code

36741

CPT Code(s)

86341

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Islet Cell Antibody Screen with Reflex to Titer - Key clinical use and differentiators
Measurement of Islet cell antigen 2 antibodies(IA-2) is used to: 1. Screen for presymptomatic T1D in individuals with a family history of type 1 diabetes (T1D) or those known to have a high-risk HLA genotype, 2. Distinguish between T1D, type 2 diabetes mellitus (T2D), and atypical forms of diabetes such as latent autoimmune diabetes in adults (LADA). [1] Positivity to IA-2 represents a key marker of T1D. [1]

Intended Clinical Use
This test is crucial for differentiating between T1D and T2D. It is important to note that classifying diabetes type ...

Test Resources

Test FAQ

Autoantibodies and Type 1 Diabetes (T1D)

Test Details

Includes

If Islet Cell Antibody Screen is positive, then Islet Cell Antibody Titer will be performed at an additional charge (CPT code(s): 86341).

Patient Preparation

Fasting specimen is preferred

Methodology

Immunofluorescence Assay (IFA)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Islet Cell Antibody Screen	Negative
Islet Cell Antibody Titer	<5 JDF units

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

If Islet Cell Antibody Screen is positive, then Islet Cell Antibody Titer will be performed at an additional charge (CPT code(s): 86341).

Patient Preparation

Fasting specimen is preferred

Methodology

Immunofluorescence Assay (IFA)

Assay Category

Reference Range(s)

Islet Cell Antibody Screen	Negative
Islet Cell Antibody Titer	<5 JDF units

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

2 mL serum

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 48 hours
Refrigerated: 14 days
Frozen: 6 months

Reject Criteria

Gross hemolysis • Grossly lipemic • Grossly icteric

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

2 mL serum

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 48 hours
Refrigerated: 14 days
Frozen: 6 months

Reject Criteria

Gross hemolysis • Grossly lipemic • Grossly icteric

Setup Schedule

Service Area must be determined

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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