Sirolimus, LC/MS/MS

Sirolimus, LC/MS/MS

Test Code

36712
80195
36712
80195
Ordering Restrictions may apply. Please provide SERVICE AREA INFORMATION to find available tests you can order.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Sirolimus, LC/MS/MS - Sirolimus is an immunosuppressant drug used to prevent organ graft rejection. Therapeutic drug monitoring is used to optimize dose and avoid toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is approximately 72 hours; in females approximately 61 hours.

Test Resources

Topic Brief

Drug Half-Life, Steady State, and Recommended Sample Collection Time

Test Guide

Solid Organ and Hematopoietic Stem Cell Transplantation Laboratory Testing for Donors and Recipients

Test Summary

Sirolimus (Rapamycin)

Test Details

Patient Preparation

Collect specimen 1 hour prior to next dose (12 hour trough)

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

3.0-18.0 ng/mL

Alternative Name(s)

Rapamycin, Rapamune®

LOINC® Codes, Performing Laboratory

Service Area must be determined
Collect specimen 1 hour prior to next dose (12 hour trough)

Methodology

Chromatography/Mass Spectrometry
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

3.0-18.0 ng/mL

Alternative Name(s)

Rapamycin, Rapamune®
Service Area must be determined

Preferred Specimen(s)

2 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

1 mL

Transport Container

EDTA (lavender-top) tube

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 5 days
  • Refrigerated: 7 days
  • Frozen: 30 days

Reject Criteria

Clotted specimen

Setup Schedule

Service Area must be determined
2 mL whole blood collected in an EDTA (lavender-top) tube
1 mL
EDTA (lavender-top) tube
Room temperature
Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days
Clotted specimen
Service Area must be determined
Ordering Restrictions may apply. Please provide SERVICE AREA INFORMATION to find available tests you can order.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.

Customize the test information for your Service Area