Carbamazepine-10,11-Epoxide, Serum/Plasma

Carbamazepine-10,11-Epoxide, Serum/Plasma

Test Code

36676
80161
36676
80161
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Carbamazepine-10,11-Epoxide, Serum/Plasma - Carbamazepine and its metabolite (10,11-Carbamazepine epoxide) are widely used for control of generalized tonic-clonic, partial-onset, complex and mixed seizure disorders. The metabolism of carbamazepine in epileptic patients has several different pathways that can be altered when the patient is co-medicated with other anticonvulsants and, therefore, its therapeutic level should be monitored along with its metabolite in their free and protein bound states.

Test Resources

Topic Brief

Drug Half-Life, Steady State, and Recommended Sample Collection Time

Test Details

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

0.2-2.0 mcg/mL

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Chromatography/Mass Spectrometry
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

0.2-2.0 mcg/mL
Service Area must be determined

Preferred Specimen(s)

2 mL serum collected in a red-top tube (no gel)

Alternative Specimen(s)

Plasma collected in: EDTA (lavender-top) tube

Minimum Volume

1 mL

Collection Instructions

Centrifuge and immediately separate serum or plasma specimens from the cells into clean, plastic transport tube.

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 14 days
  • Refrigerated: 14 days
  • Frozen: 10 months

Reject Criteria

Serum separator tube (SST)

Setup Schedule

Service Area must be determined
2 mL serum collected in a red-top tube (no gel)
Plasma collected in: EDTA (lavender-top) tube
1 mL
Centrifuge and immediately separate serum or plasma specimens from the cells into clean, plastic transport tube.
Transport tube
Room temperature
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 10 months
Serum separator tube (SST)
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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