Oxcarbazepine Metabolite

Test Code

36637

CPT Code(s)

80183

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

36637

CPT Code(s)

80183

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Ordering Restrictions may apply. Please provide SERVICE AREA INFORMATION to find available tests you can order.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Oxcarbazepine Metabolite - Oxcarbazepine (trileptal) is an anti-convulsant used for treating generalized tonic-clonic and partial seizures. It can be administered alone or as an adjunct to other anti-convulsants. Clinically significant effects of oxcarbazepine are observed when plasma levels of its active metabolite, 10-OH-carbazepine, are between 15 and 35 ug/mL. Toxic symptoms may occur when plasma levels exceed 35 ug/mL. The therapeutic monitoring of oxcarbazepine and its active metabolite are important for achieving proper serum/plasma concentration to inhibit epileptic seizures and avoid adverse effects. The precise ...

Test Resources

Topic Brief

Drug Half-Life, Steady State, and Recommended Sample Collection Time

Test Details

Includes

10-Hydroxycarbazepine

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

10-Hydroxycarbazepine

8.0-35.0 mcg/mL

Alternative Name(s)

Trileptal, Hydroxycarbazepine, 10-Hydroxycarbazepine

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

10-Hydroxycarbazepine

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Assay Category

Reference Range(s)

10-Hydroxycarbazepine

8.0-35.0 mcg/mL

Alternative Name(s)

Trileptal, Hydroxycarbazepine, 10-Hydroxycarbazepine

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

1 mL serum collected in a red-top tube (no gel)

Alternative Specimen(s)

Plasma collected in: EDTA (lavender-top) tube

Minimum Volume

0.25 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 60 days

Reject Criteria

Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

1 mL serum collected in a red-top tube (no gel)

Alternative Specimen(s)

Plasma collected in: EDTA (lavender-top) tube

Minimum Volume

0.25 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 60 days

Reject Criteria

Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Ordering Restrictions may apply. Please provide SERVICE AREA INFORMATION to find available tests you can order.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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