Beta-2-Glycoprotein I Antibody (IgM)
Test Code
Clinical Significance
Beta-2-Glycoprotein I Antibody (IgM) - Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2- Glycoprotein 1 antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.
Test Resources
Test Details
Methodology
Reference Range(s)
| Value | Interpretation |
| <20 U/mL | Antibody not detected |
| ≥20 U/mL | Antibody detected |
Preferred Specimen(s)
1 mL plasma collected in a 3.2% sodium citrate (light blue-top) tube
Alternative Specimen(s)
Serum
Minimum Volume
0.5 mL
Collection Instructions
Plasma: Centrifuge light blue-top tube for 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL).
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 5 days
- Refrigerated: 14 days
- Frozen: 30 days
Reject Criteria
Gross hemolysis • Grossly lipemic
Setup Schedule
Refrigerated: 14 days
Frozen: 30 days