ANAlyzeR™ ANA, IFA with Reflex Titer/Pattern, Systemic Autoimmune Panel 1

ANAlyzeR™ ANA, IFA with Reflex Titer/Pattern, Systemic Autoimmune Panel 1

Test Code

36378
86038, 86255, 86235 (x9), 86160 (x2), 86147 (x3), 86146 (x3), 83520 (x4), 86200, 86376
36378
86038, 86255, 86235 (x9), 86160 (x2), 86147 (x3), 86146 (x3), 83520 (x4), 86200, 86376
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

ANAlyzeR™ ANA, IFA with Reflex Titer/Pattern, Systemic Autoimmune Panel 1 - This panel can be helpful in the diagnosis of systemic rheumatic disorders and other autoimmune diseases. Although the test for antinuclear antibodies (ANA) is strongly associated with systemic lupus erythematosus (SLE), the laboratory evaluation for individuals with clinical suspicion of a variety of autoimmune diseases often begins with an ANA screen. This panel simultaneously tests for ANA (using immunofluorescence) as well as the important specific autoantibodies associated with a positive ANA. It also includes testing for complement proteins, rheumatoid arthritis, Sjogren's syndrome, systemic sclerosis, polymyositis, anti-phospholipid antibody syndrome, and autoimmune thyroid disease.

Test Resources

Test FAQ

Tests for Autoimmune Diseases (ANA)

Clinical Focus

Autoimmune Rheumatic and Related Diseases

Clinical Focus

Systemic Sclerosis: Laboratory Markers for Diagnosis and Prognosis

Test Summary

ANAlyzeR ANA, IFA with Reflex Titer/Pattern, Systemic Autoimmune Panel 1

Test Details

Includes

  • ANA Screen,IFA, with Reflex to Titer and Pattern
    DNA (ds) Antibody, Crithidia IFA with Reflex to Titer
    Chromatin (Nucleosomal) Antibody
    Sm Antibody
    Sm/RNP Antibody
    RNP Antibody
    Sjogren's Antibodies (SS-A, SS-B)
    Scleroderma Antibody (Scl-70)
    Jo-1 Antibody
    Centromere B Antibody
    Complement Component C3c and C4c
    Cardiolipin Antibodies (IgA, IgG, IgM)
    Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM)
    Rheumatoid Factor (IgA, IgG, IgM)
    Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
    Mutated Citrullinated Vimentin (MCV) Antibody
    Thyroid Peroxidase Antibodies (TPO)

    If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).

    If the DNA (ds) Antibody Screen is positive, then DNA (ds) Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

Patient Preparation

Overnight fasting is preferred

Methodology

See individual tests

Reference Range(s)

See Laboratory Report

Alternative Name(s)

Expanded ANA Antibodies,systemic lupus erythematosus,ANA and Systemic Autoimmunity,Lupus,ANA and Expanded AI Testing,Comprehensive AI Testing,Autoimmune Disorders,Systemic Autoimmune Disorder,Early Systemic Autoimmune Disease

LOINC® Codes, Performing Laboratory

Service Area must be determined
ANA Screen,IFA, with Reflex to Titer and Pattern
DNA (ds) Antibody, Crithidia IFA with Reflex to Titer
Chromatin (Nucleosomal) Antibody
Sm Antibody
Sm/RNP Antibody
RNP Antibody
Sjogren's Antibodies (SS-A, SS-B)
Scleroderma Antibody (Scl-70)
Jo-1 Antibody
Centromere B Antibody
Complement Component C3c and C4c
Cardiolipin Antibodies (IgA, IgG, IgM)
Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM)
Rheumatoid Factor (IgA, IgG, IgM)
Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
Mutated Citrullinated Vimentin (MCV) Antibody
Thyroid Peroxidase Antibodies (TPO)

If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).

If the DNA (ds) Antibody Screen is positive, then DNA (ds) Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
Overnight fasting is preferred

Methodology

See individual tests

Reference Range(s)

See Laboratory Report

Alternative Name(s)

Expanded ANA Antibodies,systemic lupus erythematosus,ANA and Systemic Autoimmunity,Lupus,ANA and Expanded AI Testing,Comprehensive AI Testing,Autoimmune Disorders,Systemic Autoimmune Disorder,Early Systemic Autoimmune Disease
Service Area must be determined

Preferred Specimen(s)

9 mL serum

Minimum Volume

6 mL

Collection Instructions

Draw three, full, 8.5 mL serum separator tubes. Allow the blood to clot for at least 30 minutes, but not longer than 1 hour before centrifugation. Centrifuge each tube for 15 minutes at 1250 to 1600 RCF. If drawn in red-top (no gel) tubes, transfer serum to transport tube(s). Place sample(s) on cold packs or in refrigerator. Sample is stable 4 days at 2-8° C (refrigerated).

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: Unacceptable
    Refrigerated: 7 days
    Frozen: 8 days

Reject Criteria

See individual tests

Setup Schedule

Service Area must be determined
9 mL serum
6 mL
Draw three, full, 8.5 mL serum separator tubes. Allow the blood to clot for at least 30 minutes, but not longer than 1 hour before centrifugation. Centrifuge each tube for 15 minutes at 1250 to 1600 RCF. If drawn in red-top (no gel) tubes, transfer serum to transport tube(s). Place sample(s) on cold packs or in refrigerator. Sample is stable 4 days at 2-8° C (refrigerated).
Transport tube
Refrigerated (cold packs)
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 8 days
See individual tests
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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