Celiac Disease Comprehensive Panel with Gliadin Antibody (IgG)

Test Code

36336

CPT Code(s)

86364, 82784

Test Code

36336

CPT Code(s)

86364, 82784

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Celiac Disease Comprehensive Panel with Gliadin Antibody (IgG) - This panel is used to assist in the diagnosis of celiac disease (CD).
Background: CD is caused by an immune response to gluten in genetically sensitive individuals. Diagnosis begins with serologic testing and is confirmed by biopsy. This panel tests all specimens for tissue transglutaminase (tTG) IgA, which has 95% sensitivity and specificity for CD. Specimens positive for tTG IgA are tested for endomysial antibody (IgA), which may increase specificity for CD. This panel also tests all specimens for total IgA. A total IgA level below the reference range is suggestive of IgA deficiency and ...

Test Resources

Test Summary

Celiac Disease Comprehensive Panel With Gliadin Antibody (IgG)

Test Details

Includes

Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)
If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s):86231).
If Endomysial Antibody (IgA) Screen is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).
If Immunoglobulin A is flagged as low based on age appropriate reference range, or if no age is provided and Immunoglobulin A result is <47 mg/dL, then Tissue Transglutaminase (tTG) Antibody (IgG) and Gliadin (Deamidated) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364, 86258).

Methodology

Immunoassay (IA) • Immunoturbidimetric Assay

Reference Range(s)

Tissue Transglutaminase (tTG) Antibody (IgA)

<15.0 U/mL	Antibody not detected
≥15.0 U/mL	Antibody detected

IgA (Immunoglobulin A)

Cord Blood	Not Established
≤3 months	5-40 mg/dL
4-6 months	7-47 mg/dL
7-11 months	12-53 mg/dL
1 year	20-73 mg/dL
2 years	20-99 mg/dL
3-5 years	22-140 mg/dL
6-8 years	31-180 mg/dL
9-11 years	33-200 mg/dL
12-16 years	36-220 mg/dL
17-60 years	47-310 mg/dL
≥61 years	70-320 mg/dL

Alternative Name(s)

Deamidated gliadin

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)

If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s):86231).
If Endomysial Antibody (IgA) Screen is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).

If Immunoglobulin A is flagged as low based on age appropriate reference range, or if no age is provided and Immunoglobulin A result is <47 mg/dL, then Tissue Transglutaminase (tTG) Antibody (IgG) and Gliadin (Deamidated) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364, 86258).

Methodology

Immunoassay (IA) • Immunoturbidimetric Assay

Reference Range(s)

Tissue Transglutaminase (tTG) Antibody (IgA)

<15.0 U/mL	Antibody not detected
≥15.0 U/mL	Antibody detected

IgA (Immunoglobulin A)

Cord Blood	Not Established
≤3 months	5-40 mg/dL
4-6 months	7-47 mg/dL
7-11 months	12-53 mg/dL
1 year	20-73 mg/dL
2 years	20-99 mg/dL
3-5 years	22-140 mg/dL
6-8 years	31-180 mg/dL
9-11 years	33-200 mg/dL
12-16 years	36-220 mg/dL
17-60 years	47-310 mg/dL
≥61 years	70-320 mg/dL

Alternative Name(s)

Deamidated gliadin

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

5 mL serum

Minimum Volume

1 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria

Gross hemolysis • Grossly lipemic

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

5 mL serum

Minimum Volume

1 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria

Gross hemolysis • Grossly lipemic

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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