Infliximab Anti-drug Antibody for IBD
Test Code
36301
83520
In-home collection is not available in your area through Quest Mobile.
Clinical Significance
Infliximab Anti-drug Antibody for IBD - When treatment of inflammatory bowel disease with infliximab or its biosimilar fails, a physician may need to consider treatment options, such as adjusting dose or dosing intervals, switching to a different TNF blocker, or switching to a different drug agent, i.e. a non-TNF blocker. This assay specifically detects antibodies to infliximab and infliximab-dyyb (inflectra) that may reduce serum levels of the drug, as well as its clinical efficacy.
Test Resources
Test Details
For up to 48 hours before blood draw, do not take multivitamins or dietary supplements containing biotin or vitamin B7. Fasting not required.
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range(s)
<10 AU
Alternative Name(s)
ATI,Anti-Inflectra antibodies,Anti-TNF-alpha blocker antibody,Anti-infliximab IgG,Anti-infliximab antibodies,Anti-Remicade® antibody,Human Anti-Chimeric Antibody,Anti-IFX Abs,Antibodies-to-infliximab
Preferred Specimen(s)
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.5 mL
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 48 hours
- Refrigerated: 7 days
- Frozen -20° C: 28 days
- Frozen -70° C: 70 days
Reject Criteria
Gross hemolysis • Serum separator tube (SST) • Grossly icteric
Setup Schedule
1 mL serum collected in a red-top tube (no gel)
0.5 mL
Transport tube
Refrigerated (cold packs)
Room temperature: 48 hours
Refrigerated: 7 days
Frozen -20° C: 28 days
Frozen -70° C: 70 days
Refrigerated: 7 days
Frozen -20° C: 28 days
Frozen -70° C: 70 days
Gross hemolysis • Serum separator tube (SST) • Grossly icteric