Collagen Cross-Linked N-Telopeptide (NTx), Urine

Test Code

36167

CPT Code(s)

82523, 82570

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

36167

CPT Code(s)

82523, 82570

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Collagen Cross-Linked N-Telopeptide (NTx), Urine - NTx is useful to assess bone resorption in patients with metabolic bone disease. The test is also useful in monitoring therapy to slow or halt osteoporotic bone loss. A decline of 30% or more of NTx over a six-month period suggests effective therapy.

Test Resources

None found for this test
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Test Details

Includes

Creatinine

Methodology

Chemiluminescence (CL)

Reference Range(s)

Collagen Cross-Linked N-Telopeptide (NTx), Random Urine

Male
18-29 Years	12-99 nM BCE/mM creat
30-59 Years	9-60 nM BCE/mM creat
Female
Premenopausal	4-64 nM BCE/mM creat

Results are primarily used for monitoring the response to therapy. A value within the premenopausal reference range does not rule out osteoporosis nor the need for therapy.

Creatinine, Random Urine

≤6 Months	2-28 mg/dL
7-11 Months	2-31 mg/dL
1-2 Years	2-110 mg/dL
3-8 Years	2-130 mg/dL
9-12 Years	2-160 mg/dL
>12 Years Male	20-320 mg/dL
>12 Years Female	20-275 mg/dL

Alternative Name(s)

Collagen Cross-Linked N-Telopeptide,N-Telopeptide or NTx

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

Creatinine

Methodology

Chemiluminescence (CL)

Reference Range(s)

Collagen Cross-Linked N-Telopeptide (NTx), Random Urine

Male
18-29 Years	12-99 nM BCE/mM creat
30-59 Years	9-60 nM BCE/mM creat
Female
Premenopausal	4-64 nM BCE/mM creat

≤6 Months	2-28 mg/dL
7-11 Months	2-31 mg/dL
1-2 Years	2-110 mg/dL
3-8 Years	2-130 mg/dL
9-12 Years	2-160 mg/dL
>12 Years Male	20-320 mg/dL
>12 Years Female	20-275 mg/dL

Alternative Name(s)

Collagen Cross-Linked N-Telopeptide,N-Telopeptide or NTx

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

2 mL unpreserved urine collected from second morning void

Alternative Specimen(s)

Unpreserved random urine • Unpreserved catheterized urine • Unpreserved first void clean catch urine

Minimum Volume

1 mL

Collection Instructions

Do not use preservatives. Acidified specimen is not acceptable.

Second morning void urine: Discard the first morning void. Collect the second morning void. Mix well.

Transport Container

Sterile screw-cap container

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 5 days
Frozen: 30 days

Reject Criteria

Acidified specimen • Preserved specimen

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

2 mL unpreserved urine collected from second morning void

Alternative Specimen(s)

Unpreserved random urine • Unpreserved catheterized urine • Unpreserved first void clean catch urine

Minimum Volume

1 mL

Collection Instructions

Do not use preservatives. Acidified specimen is not acceptable.

Second morning void urine: Discard the first morning void. Collect the second morning void. Mix well.

Transport Container

Sterile screw-cap container

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 5 days
Frozen: 30 days

Reject Criteria

Acidified specimen • Preserved specimen

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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