Methylmalonic Acid

Test Code

34879

CPT Code(s)

83921

Test Code

34879

CPT Code(s)

83921

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Methylmalonic Acid - The Methylmalonic Acid (MMA) test is used in the diagnosis of acquired cobalamin (vitamin B12) deficiency in adults and to screen for inherited organic acidemia in neonates and infants. Elevated MMA in either blood or urine indicates vitamin B12 deficiency in adults, with MMA acting as a functional biomarker for vitamin B12 status. In neonates and infants, elevated MMA is associated with inborn errors of metabolism.

Adults with signs and symptoms of cobalamin deficiency, including peripheral neuropathy, ataxia, memory impairment, depression, behavioral changes, and anemia, should be tested ...

Test Resources

None found for this test
Please visit our Clinical Education Center to stay informed on any future publications, webinars, or other education opportunities.

Test Details

Methodology

Mass Spectrometry (MS)

Reference Range(s)

≤30 days	87-580 nmol/L
31 days-11 months	62-377 nmol/L
12-23 months	55-347 nmol/L
2-59 years	55-335 nmol/L
60-79 years	69-390 nmol/L
≥80 years	85-423 nmol/L

Alternative Name(s)

MMA

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Mass Spectrometry (MS)

Reference Range(s)

≤30 days	87-580 nmol/L
31 days-11 months	62-377 nmol/L
12-23 months	55-347 nmol/L
2-59 years	55-335 nmol/L
60-79 years	69-390 nmol/L
≥80 years	85-423 nmol/L

Alternative Name(s)

MMA

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

2 mL serum

Alternative Specimen(s)

Serum collected in: Royal blue-top tube • Plasma collected in: Sodium heparin (green-top) or sodium heparin (royal blue-top) tube

Minimum Volume

1 mL

Transport Container

Serum separator tube (SST)

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 10 months

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

2 mL serum

Alternative Specimen(s)

Serum collected in: Royal blue-top tube • Plasma collected in: Sodium heparin (green-top) or sodium heparin (royal blue-top) tube

Minimum Volume

1 mL

Transport Container

Serum separator tube (SST)

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 10 months

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.