Tryptase

Test code

34484

CPT code(s)*

83520

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Clinical significance

Tryptase - This test may be used as a marker of mast cell activity. Tryptase is a serine protease released by mast cells constitutively (alpha-tryptase) and during activation (beta-tryptase). Serum measurement detects both forms and does not differentiate them [1]. Elevated basal tryptase levels are not uncommon and in most cases are due to hereditary alpha tryptasemia [2]. They are also seen in mastocytosis, other myeloid disorders, allergic disorders, chronic renal failure and some chronic infections [3]. Using tryptase to confirm anaphylaxis may require drawing the sample within 30 minutes - 6 hours of the suspected event and comparison with baseline levels drawn at least 24…

Test resources

None found for this test
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Details

Test details

Methodology

Immunoassay (IA)

Specimen requirements
Patient preparation	None Specified
Preferred specimen(s)	1 mL serum
Minimum volume	0.5 mL
Collection instructions	Samples should be obtained between 15 minutes and 3 hours after the event suspected of causing mast cell activation. When sample is drawn, separate serum from cells within 3 hours of collection.
Transport container	Transport tube
Transport temperature	Refrigerated (cold-packs)
Specimen stability	Room temperature: Unacceptable Refrigerated: 7 days Frozen: 30 days

Reference range(s)

<11.0 mcg/L

LOINC® codes

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Service Area Information

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.