Lyme Disease Antibody Index for CNS Infection
Test Code
34194
82040, 82042, 82784 (x2), 86618 (x4)
In-home collection is not available in your area through Quest Mobile.
Clinical Significance
Lyme Disease Antibody Index for CNS Infection - The Lyme disease antibody index is used as an aid for diagnosing neuroborreliosis. The assay requires paired serum and CSF. A result set of lyme disease antibody index >1.2, control antibody index <1.0, and albumin ratio <0.0078 provides strong evidence of intrathecal synthesis of b. Burgdorferi antibodies and supports the diagnosis of neuroborreliosis.
Test Resources
Test FAQ
Lyme Disease TestingClinical Focus
Lyme Disease: Laboratory Support of Diagnosis and ManagementTest Details
Methodology
Enzyme Linked Immunosorbent Immunoassay (ELISA) • Nephelometry
Reference Range(s)
Lyme Disease Antibody Index
| ≤1.0 | Negative |
| 1.1-1.2 | Equivocal |
| ≥1.3 | Positive |
| Control Antibody Index | ≤1.0 |
| Albumin Ratio | <0.0078 |
Preferred Specimen(s)
2 mL serum and
2 mL CSF collected in a sterile leak-proof container within a 24-hour period
Minimum Volume
1 mL serum • 1 mL CSF
Collection Instructions
2 mL serum and 2 mL CSF collected within a 24-hour period
Transport Container
Transport tube and Sterile leak-proof container
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: 30 days
Reject Criteria
CSF and serum collected greater than 24 hours apart
Setup Schedule
2 mL serum and
2 mL CSF collected in a sterile leak-proof container within a 24-hour period
2 mL CSF collected in a sterile leak-proof container within a 24-hour period
1 mL serum • 1 mL CSF
2 mL serum and 2 mL CSF collected within a 24-hour period
Transport tube and Sterile leak-proof container
Room temperature
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
CSF and serum collected greater than 24 hours apart