IgA Subclasses

Test code

34188

CPT code(s)*

82784, 82787 (x2)

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Clinical significance

IgA Subclasses - IgA, the predominant immunoglobulin secreted at mucosal surfaces, consists of 2 subclasses. IgA1 is the major subclass and accounts for 80% of total IgA in serum, whereas IgA2 is the major subclass in secretions such as milk.Low concentrations of IgA2 with normal IgA1 levels suggest an IgA2 deficiency.Antigenic sites on the IgA subclasses are responsible for the anaphylactic transfusion reactions experienced by some patients totally deficient in either IgA1 or IgA2. After repeated transfusions, such patients may produce antibodies to these antigens. Thus, IgA subclasses are useful in evaluating patients with anaphylactic transfusion reactions.Elevated…

Test resources

None found for this test
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Details

Test details

Includes

IgA1, IgA2, and IgA, Serum

Methodology

Immunoturbidimetry

Specimen requirements
Patient preparation	Fasting preferred
Preferred specimen(s)	2 mL serum
Minimum volume	1 mL
Transport container	Transport tube
Transport temperature	Room temperature
Specimen stability	Room temperature: 5 days Refrigerated: 15 days Frozen: 30 days
Reject criteria	Gross hemolysis • Lipemia

Reference range(s)

Reference Range(s)

IgA1
6-11 months	1-115 mg/dL
1 year	3-120 mg/dL
2 years	7-132 mg/dL
3 years	11-143 mg/dL
4-7 years	23-175 mg/dL
8-11 years	33-204 mg/dL
12-17 years	47-249 mg/dL
≥18 years	46-378 mg/dL

IgA2
6-11 months	0-19 mg/dL
1 year	0-23 mg/dL
2 years	1-23 mg/dL
3 years	1-25 mg/dL
4-7 years	2-33 mg/dL
8-11 years	2-37 mg/dL
12-17 years	4-50 mg/dL
≥18 years	13-91 mg/dL

IgA, Serum
Cord Blood	1-3 mg/dL
1-28 days	2-40 mg/dL
1-3 months	3-40 mg/dL
4-6 months	7-47 mg/dL
7-11 months	12-53 mg/dL
1 year	20-73 mg/dL
2 years	20-99 mg/dL
3-5 years	22-140 mg/dL
6-8 years	31-180 mg/dL
9-11 years	33-200 mg/dL
12-16 years	36-220 mg/dL
17-60 years	47-310 mg/dL
≥61 years	70-320 mg/dL

LOINC® codes

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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