Cholinesterase, Plasma

Cholinesterase, Plasma

Test Code

335
82480
335
82480
Ordering Restrictions may apply. Please provide SERVICE AREA INFORMATION to find available tests you can order.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Cholinesterase, Plasma - Approximately 1 in every 2500 individuals has inherited defective or deficiency of the enzyme (pseudocholinesterase) that metabolizes succinylcholine (an anesthetic agent). With "normal" dosage, these individuals have prolonged apnea. Such individuals are responsive at much smaller concentrations of this anesthetic agent than the general population. Low concentrations of pseudocholinesterase are observed in individuals exposed to organophosphorous insecticides and patients with hepatic dysfunction.

Test Resources

None found for this test
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Test Details

Methodology

Kinetic Spectrophotometric (KS)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

This test code is for non-California patient testing. For California patient testing, use test code 90368.

Reference Range(s)

Male 3334-7031 IU/L
Female 2504-6297 IU/L

Alternative Name(s)

Pseudocholinesterase

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Kinetic Spectrophotometric (KS)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

This test code is for non-California patient testing. For California patient testing, use test code 90368.

Reference Range(s)

Male 3334-7031 IU/L
Female 2504-6297 IU/L

Alternative Name(s)

Pseudocholinesterase
Service Area must be determined

Preferred Specimen(s)

1 mL plasma collected in an EDTA (lavender-top) tube

Minimum Volume

0.5 mL

Collection Instructions

Draw an EDTA (lavender-top) tube of whole blood. Spin tube to separate plasma. Pour plasma into plastic aliquot tube and refrigerated until shipping. Ship plasma sample refrigerated. Do not send packed cells. Do not send one tube of whole blood.
Plasma cholinesterase results are not accurate if plasma sample is not separated from RBCs in a timely manner (within 1 hour). Hemolyzed plasma can lead to apparent increases in plasma cholinesterase activity, and could mask an enzyme deficiency.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 21 days
  • Refrigerated: 21 days 
  • Frozen: 30 days

Reject Criteria

Hemolysis

Setup Schedule

Service Area must be determined
1 mL plasma collected in an EDTA (lavender-top) tube
0.5 mL

Draw an EDTA (lavender-top) tube of whole blood. Spin tube to separate plasma. Pour plasma into plastic aliquot tube and refrigerated until shipping. Ship plasma sample refrigerated. Do not send packed cells. Do not send one tube of whole blood.
Plasma cholinesterase results are not accurate if plasma sample is not separated from RBCs in a timely manner (within 1 hour). Hemolyzed plasma can lead to apparent increases in plasma cholinesterase activity, and could mask an enzyme deficiency.

Transport tube
Refrigerated (cold packs)
Room temperature: 21 days
Refrigerated: 21 days 
Frozen: 30 days
Hemolysis
Service Area must be determined
Ordering Restrictions may apply. Please provide SERVICE AREA INFORMATION to find available tests you can order.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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