Valproic Acid, Free

Test Code

3314

CPT Code(s)

80165

Test Code

3314

CPT Code(s)

80165

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Valproic Acid, Free - Valproic acid is used as an anticonvulsant to treat certain types of seizures, to prevent migraine headahces, and to treat various psychiatric illnesses such as bipolar disorder and aggression. Drugs that compete from protein-binding sites with valproic acid, can increase the concentration of valproic acid. Measurement of the free concentration is useful if toxicity is suspected.

Test Resources

Topic Brief

Drug Half-Life, Steady State, and Recommended Sample Collection Time

Test Details

Patient Preparation

Avoid contact of samples with plasticizers, varnishes, paint fumes, and fatty acids.
Collect as trough just before next dose (optimum time to collect sample: 1 hour before next dose).

Methodology

Immunoassay (IA)

Reference Range(s)

4.8-17.3 mg/L

LOINC® Codes, Performing Laboratory

Service Area must be determined

Patient Preparation

Avoid contact of samples with plasticizers, varnishes, paint fumes, and fatty acids.
Collect as trough just before next dose (optimum time to collect sample: 1 hour before next dose).

Methodology

Immunoassay (IA)

Reference Range(s)

4.8-17.3 mg/L

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

3 mL serum collected in a red-top tube (no gel)

Alternative Specimen(s)

Serum collected in: No additive (royal blue-top) tube • Plasma collected in: EDTA (lavender-top) or EDTA (royal blue-top) tube

Minimum Volume

1 mL

Collection Instructions

Do not use gel barrier tubes. Centrifuge and immediately separate serum or plasma specimens from the cells into clean transport tube.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 60 days

Reject Criteria

Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

3 mL serum collected in a red-top tube (no gel)

Alternative Specimen(s)

Serum collected in: No additive (royal blue-top) tube • Plasma collected in: EDTA (lavender-top) or EDTA (royal blue-top) tube

Minimum Volume

1 mL

Collection Instructions

Do not use gel barrier tubes. Centrifuge and immediately separate serum or plasma specimens from the cells into clean transport tube.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 60 days

Reject Criteria

Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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