Chromogranin A, LC/MS/MS

Test Code

31911

CPT Code(s)

86316

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

31911

CPT Code(s)

86316

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Chromogranin A, LC/MS/MS - Chromogranin-A (CgA) is an acidic glycoprotein expressed in the secretory granules of most normal and neoplastic neuroendocrine (NE) cell types, where it is released together with peptide hormones and biogenic amines. Neuroendocrine tumors (NETs) are a form of cancer that differ from other neoplasia in that they synthesize, store, and secrete peptides, e.g., CgA and amines. CgA is secreted from neuroendocrine-derived tumors including foregut, midgut and hindgut gastrointestinal NETs, pheochromocytomas, neuroblastomas, medullary thyroid carcinomas, some pituitary tumors, functioning and non-functioning ...

Test Resources

Test FAQ

Chromogranin A Testing

Test Details

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Adults

<311 ng/mL

Alternative Name(s)

CgA

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Chromatography/Mass Spectrometry

Assay Category

Reference Range(s)

Adults

<311 ng/mL

Alternative Name(s)

CgA

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

1 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.5 mL

Collection Instructions

Collect blood in a standard red-top serum vacutainer tube. Allow blood to clot at room temperature. Centrifuge and separate the serum from the cells immediately. Do not store refrigerated.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: 7 days
Refrigerated: Unacceptable
frozen: 31 days

Reject Criteria

Gross hemolysis • Unspun red-top (no gel) tubes • Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

1 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.5 mL

Collection Instructions

Collect blood in a standard red-top serum vacutainer tube. Allow blood to clot at room temperature. Centrifuge and separate the serum from the cells immediately. Do not store refrigerated.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: 7 days
Refrigerated: Unacceptable
frozen: 31 days

Reject Criteria

Gross hemolysis • Unspun red-top (no gel) tubes • Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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