Catecholamines, Fractionated, 24-Hour Urine without Creatinine

Catecholamines, Fractionated, 24-Hour Urine without Creatinine

Test Code

318
82384
318
82384
Ordering Restrictions may apply. Please provide SERVICE AREA INFORMATION to find available tests you can order.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Catecholamines, Fractionated, 24-Hour Urine without Creatinine - The three catecholamines (norepinephrine, epinephrine and dopamine) are the principal secretory products of neural tissue. Clinically, the measurement of circulating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas and gangliomas) and with the evaluation of orthostatic hypotension.

Test Resources

None found for this test
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Test Details

Includes

  • Epinephrine, Norepinephrine, Calculated Total (E+NE), Dopamine

    CPT code 81050 may be added at an additional charge for volume measurement

Patient Preparation

It is preferable for the patient to be off medications for a minimum of 18-24 hours prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) may cause minimal or no interference.
Patient should avoid tobacco, tea, coffee, and strenuous exercise for 8-12 hours prior to collection.

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Epinephrine, 24 hr Urine

PediatricNot Established
Adults≤24 mcg/24 h

Norepinephrine, 24 hr Urine
PediatricNot Established
Adults≤100 mcg/24 h

Calculated Total (E+NE)
PediatricNot Established
Adults26-121 mcg/24 h

Dopamine, 24 hr Urine
PediatricNot Established
Adults52-480 mcg/24 h

Alternative Name(s)

Catecholamines, Free,Adrenaline,Noradrenaline

LOINC® Codes, Performing Laboratory

Service Area must be determined
Epinephrine, Norepinephrine, Calculated Total (E+NE), Dopamine

CPT code 81050 may be added at an additional charge for volume measurement
It is preferable for the patient to be off medications for a minimum of 18-24 hours prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) may cause minimal or no interference.
Patient should avoid tobacco, tea, coffee, and strenuous exercise for 8-12 hours prior to collection.

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Epinephrine, 24 hr Urine
PediatricNot Established
Adults≤24 mcg/24 h

Norepinephrine, 24 hr Urine
PediatricNot Established
Adults≤100 mcg/24 h

Calculated Total (E+NE)
PediatricNot Established
Adults26-121 mcg/24 h

Dopamine, 24 hr Urine
PediatricNot Established
Adults52-480 mcg/24 h

Alternative Name(s)

Catecholamines, Free,Adrenaline,Noradrenaline
Service Area must be determined

Preferred Specimen(s)

1 mL preserved 24-hour urine with 25 mL 6N HCl collected in a plastic 24-hour urine container

Alternative Specimen(s)

Unpreserved 24-hour urine with pH ≤6

Minimum Volume

0.7 mL

Collection Instructions

Collect 24-hour urine with 25 mL 6N HCL to maintain a pH ≤3. If no preservative is used, specimen must be stored refrigerated during collection but shipped frozen and pH must be ≤6.
Record 24-hour urine volume and patient's age on test request form and on urine container.

Transport Container

Plastic urine container

Transport Temperature

Frozen

Reject Criteria

Preserved urine received refrigerated with pH >3 • Unpreserved urine received frozen with pH >6

Setup Schedule, Specimen Stability

Service Area must be determined
1 mL preserved 24-hour urine with 25 mL 6N HCl collected in a plastic 24-hour urine container
Unpreserved 24-hour urine with pH ≤6
0.7 mL
Collect 24-hour urine with 25 mL 6N HCL to maintain a pH ≤3. If no preservative is used, specimen must be stored refrigerated during collection but shipped frozen and pH must be ≤6.
Record 24-hour urine volume and patient's age on test request form and on urine container.
Plastic urine container
Frozen
Preserved urine received refrigerated with pH >3 • Unpreserved urine received frozen with pH >6
Service Area must be determined
Ordering Restrictions may apply. Please provide SERVICE AREA INFORMATION to find available tests you can order.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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