Catecholamines, Fractionated, Plasma

Catecholamines, Fractionated, Plasma

Test Code

314
82384
314
82384
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Catecholamines, Fractionated, Plasma -

This panel may aid in evaluating catecholamine-producing pheochromocytomas and paragangliomas (PPGLs). However, measurements of plasma free or urinary fractionated metanephrines (ie, the O-methylated catecholamine metabolites) are preferred for the initial biochemical evaluation of PPGLs because of their overall high diagnostic sensitivity [1].

Most PPGLs secrete catecholamines and can cause catecholamine excess, resulting in hypertension, arrhythmia, and hyperglycemia. Left untreated, PPGLs often lead to life-threatening cardiovascular complications. The estimated prevalence of PPGLs ...

Test Resources

None found for this test
Please visit our Clinical Education Center to stay informed on any future publications, webinars, or other education opportunities.

Test Details

Includes

  • Dopamine, Epinephrine, Norepinephrine and Total Catecholamines (calculated)

Patient Preparation

Patients should be relaxed in either a supine or upright position before blood is drawn. States of anxiety and stress can cause fluctuations in the catecholamine levels. Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise prior to collection. Overnight fasting is preferred.

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Catecholamines, Total (<18 years)Not established
  
Catecholamines, Total (≥18 years)
Epinephrine
  Supine<58 pg/mL
  Upright<82 pg/mL
  
Norepinephrine
  Supine149-564 pg/mL
  Upright199-937 pg/mL
  
Dopamine
  Supine<16 pg/mL
  Upright<27 pg/mL
  
Total Catecholamines
  Supine<632 pg/mL
  Upright<1046 pg/mL

Alternative Name(s)

Catecholamines, Free,Dopamine,Epinephrine,Noradrenalin,Adrenaline,Norepinephrine

LOINC® Codes, Performing Laboratory

Service Area must be determined
Dopamine, Epinephrine, Norepinephrine and Total Catecholamines (calculated)
Patients should be relaxed in either a supine or upright position before blood is drawn. States of anxiety and stress can cause fluctuations in the catecholamine levels. Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise prior to collection. Overnight fasting is preferred.

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Catecholamines, Total (<18 years)Not established
  
Catecholamines, Total (≥18 years)
Epinephrine
  Supine<58 pg/mL
  Upright<82 pg/mL
  
Norepinephrine
  Supine149-564 pg/mL
  Upright199-937 pg/mL
  
Dopamine
  Supine<16 pg/mL
  Upright<27 pg/mL
  
Total Catecholamines
  Supine<632 pg/mL
  Upright<1046 pg/mL

Alternative Name(s)

Catecholamines, Free,Dopamine,Epinephrine,Noradrenalin,Adrenaline,Norepinephrine
Service Area must be determined

Preferred Specimen(s)

2 mL frozen plasma collected in a sodium heparin (green-top) tube

Alternative Specimen(s)

Frozen plasma collected in: EDTA (lavender-top) tube

Minimum Volume

1 mL

Collection Instructions

Draw specimen in a pre-chilled green-top vacutainer. After drawing specimen, place green-top tube in an ice bath. Centrifuge 20 minutes 1000xg. The plasma must be free of RBCs. Freeze on dry ice to transport.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: 6 hours

  • Refrigerated: 6 hours
  • Frozen: 30 days

Reject Criteria

Received room temperature • Received refrigerated

Setup Schedule

Service Area must be determined
2 mL frozen plasma collected in a sodium heparin (green-top) tube
Frozen plasma collected in: EDTA (lavender-top) tube
1 mL
Draw specimen in a pre-chilled green-top vacutainer. After drawing specimen, place green-top tube in an ice bath. Centrifuge 20 minutes 1000xg. The plasma must be free of RBCs. Freeze on dry ice to transport.
Transport tube
Frozen

Room temperature: 6 hours
Refrigerated: 6 hours
Frozen: 30 days

Received room temperature • Received refrigerated
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.

Customize the test information for your Service Area
We'd love your feedback! Take a brief survey.