ACTH, Plasma

Test code

211

CPT code(s)*

82024

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Clinical significance

ACTH, Plasma - Adrenocorticotropic hormone (ACTH) or corticotropin is a peptide hormone consisting of 39 amino acids. It is produced in the anterior pituitary of the brain as part of the precursor molecule pro-opiomelanocortin (POMC). Tissue- specific cleavage results in ACTH and a range of relatedpeptides. ACTH stimulates formation and secretion of glucocorticoids (especially cortisol) by the adrenal cortex.Glucocorticoid production is regulated by various factors. After stimulation (e.g. by physical effort or by the internal body clock), the hypothalamus secretes CRH (corticotropin releasing hormone). CRH acts on the pituitary, which in turn synthesizes and secretes ACTH.…

Test resources

None found for this test
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Details

Test details

Methodology

Electrochemiluminescence

Alternative name(s)

Adrenocorticotropic Hormone,Corticotropin

Specimen requirements
Patient preparation	ACTH measurement is not recommended for patients who have been administered cosyntropin (ACTH(1-24)) because the results may be falsely elevated or depressed
Preferred specimen(s)	1.5 mL frozen plasma collected in an EDTA (lavender-top) tube
Minimum volume	0.5 mL
Collection instructions	Collect specimens between 7 a.m. and 10 a.m. If drawn during any other time, the reference ranges do not apply. Only use pre-chilled EDTA tube. After drawing the blood, put the tube immediately on ice. Centrifuge immediately to separate the plasma. Plasma should be transferred to a pre-chilled plastic transport container and frozen immediately.
Transport container	Transport tube
Transport temperature	Frozen
Specimen stability	Room temperature: Unacceptable Refrigerated: Unacceptable Frozen: 32 days
Reject criteria	Plasma other than EDTA plasma

Reference range(s)

7.2-63.3 pg/ml

LOINC® codes

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Service Area Information

Performing lab & setup schedule

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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