Acetylcholine Receptor Binding Antibody
Test Code
206
86041
Clinical Significance
Acetylcholine Receptor Binding Antibody - Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. This assay aids in the differential diagnosis of conditions with MG-like muscle weakness and in monitoring therapeutic response. If binding antibodies are negative, assays for modulating and blocking antibodies should be considered.
Test Resources
Clinical Focus
Myasthenia Gravis and AutoantibodiesTest Details
Methodology
Radioimmunoassay (RIA)
Reference Range(s)
| Negative | ≤0.30 nmol/L | |
| Equivocal | 0.31-0.49 nmol/L | |
| Positive | ≥0.50 nmol/L | |
Preferred Specimen(s)
1 mL serum
Minimum Volume
0.5 mL
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 14 days
- Refrigerated: 14 days
- Frozen: 30 days
Reject Criteria
Gross hemolysis • Grossly lipemic • Microbially contaminated
Setup Schedule
1 mL serum
0.5 mL
Transport tube
Room temperature
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Gross hemolysis • Grossly lipemic • Microbially contaminated