Celiac Disease Comprehensive Panel

Test Code

19955

CPT Code(s)

86364, 82784

Test Code

19955

CPT Code(s)

86364, 82784

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Celiac Disease Comprehensive Panel - Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.
Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.

Test Resources

Test Summary

Celiac Disease Comprehensive Panel With Gliadin Antibody (IgG)

Test Details

Includes

Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)
If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86231).
If Endomysial Antibody Screen (IgA) is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).
If Immunoglobulin A is less than the lower limit of the reference range, based on age, then Tissue Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364).

Methodology

Immunoassay (IA) • Immunoturbidimetric

Reference Range(s)

Tissue Transglutaminase (tTG) Antibody (IgA)

<15.0 U/mL		Antibody not detected
≥15.0 U/mL		Antibody detected

IgA (Immunoglobulin A)

Cord Blood	Not Established
≤3 months	5-40 mg/dL
4-6 months	7-47 mg/dL
7-11 months	12-53 mg/dL
1 year	20-73 mg/dL
2 years	20-99 mg/dL
3-5 years	22-140 mg/dL
6-8 years	31-180 mg/dL
9-11 years	33-200 mg/dL
12-16 years	36-220 mg/dL
17-60 years	47-310 mg/dL
≥61 years	70-320 mg/dL

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)

If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86231).
If Endomysial Antibody Screen (IgA) is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).

If Immunoglobulin A is less than the lower limit of the reference range, based on age, then Tissue Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364).

Methodology

Immunoassay (IA) • Immunoturbidimetric

Reference Range(s)

Tissue Transglutaminase (tTG) Antibody (IgA)

<15.0 U/mL		Antibody not detected
≥15.0 U/mL		Antibody detected

IgA (Immunoglobulin A)

Cord Blood	Not Established
≤3 months	5-40 mg/dL
4-6 months	7-47 mg/dL
7-11 months	12-53 mg/dL
1 year	20-73 mg/dL
2 years	20-99 mg/dL
3-5 years	22-140 mg/dL
6-8 years	31-180 mg/dL
9-11 years	33-200 mg/dL
12-16 years	36-220 mg/dL
17-60 years	47-310 mg/dL
≥61 years	70-320 mg/dL

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

5 mL serum

Minimum Volume

1 mL

Transport Container

Transport tube

Specimen Stability

Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria

Gross hemolysis • Grossly lipemic

Setup Schedule, Transport Temperature

Service Area must be determined

Preferred Specimen(s)

5 mL serum

Minimum Volume

1 mL

Transport Container

Transport tube

Specimen Stability

Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria

Gross hemolysis • Grossly lipemic

Setup Schedule, Transport Temperature

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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