Cortisol, LC/MS, Saliva

Cortisol, LC/MS, Saliva

Test Code

19897
82530
19897
82530
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Cortisol, LC/MS, Saliva -

Salivary cortisol level, particularly late-night salivary cortisol (LNSC) level, is useful in screening for endogenous Cushing syndrome. Two or more positive results of LNSC tests may be used to confirm Cushing syndrome. LNSC measurement may also be used to monitor for recurrence of Cushing disease [1].

Normally, the secretion of cortisol has a circadian rhythm. Patients with Cushing syndrome often lose the late-night circadian nadir. Therefore, an elevated LNSC level may provide initial evidence for Cushing syndrome. Two or more positive results of LNSC tests may establish the diagnosis ...

Test Resources

Algorithm

Polycystic Ovary Syndrome (PCOS) Diagnostic Algorithm

Clinical Focus

Polycystic Ovary Syndrome (PCOS)

Test Details

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

8-10 AM0.04-0.56 mcg/dL
Noon-2 PM≤0.21 mcg/dL
4-6 PM≤0.15 mcg/dL
10 PM-1 AM≤0.09 mcg/dL

Alternative Name(s)

Compound F,Hydrocortisone

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Chromatography/Mass Spectrometry
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

8-10 AM0.04-0.56 mcg/dL
Noon-2 PM≤0.21 mcg/dL
4-6 PM≤0.15 mcg/dL
10 PM-1 AM≤0.09 mcg/dL

Alternative Name(s)

Compound F,Hydrocortisone
Service Area must be determined

Preferred Specimen(s)

0.5 mL saliva collected in a Salivette® Cortisol with blue screw-cap

Alternative Specimen(s)

Super SAL™ or Super SAL2™ Universal Saliva Kit

Minimum Volume

0.2 mL

Collection Instructions

a. Saliva collection should be done at the earliest 60 minutes after brushing teeth, a meal (liquid/solid food intake) or oral intake of medication and 10 minutes after rinsing the mouth with water in order to avoid contamination of the saliva by interfering substances.

b. Remove the swab from the Salivette.

c. Place the swab in the mouth, e.g. in your cheek, where it should remain for 2 minutes without chewing. If an extremely small amount of saliva is produced, leave the swab in the mouth for longer.

d. Return the swab with the absorbed saliva to the Salivette.

e. Replace the stopper.

f. Refrigerate the Salivette immediately.

Transport Container

Salivette Cortisol with blue screw-cap

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 72 hours
    Refrigerated: 21 days
    Frozen: 6 months

Reject Criteria

Hemolysis • White-top Salivette collection devices

Setup Schedule

Service Area must be determined
0.5 mL saliva collected in a Salivette® Cortisol with blue screw-cap
Super SAL™ or Super SAL2™ Universal Saliva Kit
0.2 mL
a. Saliva collection should be done at the earliest 60 minutes after brushing teeth, a meal (liquid/solid food intake) or oral intake of medication and 10 minutes after rinsing the mouth with water in order to avoid contamination of the saliva by interfering substances.

b. Remove the swab from the Salivette.

c. Place the swab in the mouth, e.g. in your cheek, where it should remain for 2 minutes without chewing. If an extremely small amount of saliva is produced, leave the swab in the mouth for longer.

d. Return the swab with the absorbed saliva to the Salivette.

e. Replace the stopper.

f. Refrigerate the Salivette immediately.
Salivette Cortisol with blue screw-cap
Refrigerated (cold packs)
Room temperature: 72 hours
Refrigerated: 21 days
Frozen: 6 months
Hemolysis • White-top Salivette collection devices
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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