Lupus Panel 3 with ANA, IFA with Reflex to Titer and Pattern

Test Code

19881

CPT Code(s)

86038, 86225, 86235 (x5), 86160 (x2), 86162

Test Code

19881

CPT Code(s)

86038, 86225, 86235 (x5), 86160 (x2), 86162

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Lupus Panel 3 with ANA, IFA with Reflex to Titer and Pattern - This panel can be helpful in the diagnosis and management of systemic lupus erythematosus (SLE). The panel simultaneously tests for antinuclear antibodies (ANAs) with an immunofluorescence assay (IFA), performed on human epithelial type 2 (HEp-2) cells, as well as 6 specific autoantibodies associated with SLE and 3 biomarkers associated with disease activity. For specimens with positive ANA IFA results, reflex testing for ANA titer and pattern is performed.

The ANA testing has high sensitivity (97%) for SLE but limited specificity (34%) [1]. Anti-dsDNA and anti-Sm antibodies are less sensitive ...

Test Resources

Clinical Focus

Autoimmune Rheumatic and Related Diseases

Test Details

Includes

ANA Screen, IFA, with Reflex to Titer and Pattern
DNA (ds) Antibody
Sjogren's Antibodies (SS-A, SS-B)
Sm Antibody
RNP Antibody
Chromatin (Nucleosomal) Antibody
Complement Component C3c and C4c
Complement, Total (CH50)

If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).

Methodology

See individual tests

Reference Range(s)

See Laboratory Report

Alternative Name(s)

Systemic Lupus Erythematosus (SLE),FANA,Antinuclear Antibody Screen,Fluorescent ANA,Hep-2,Progressive ANA

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

ANA Screen, IFA, with Reflex to Titer and Pattern
DNA (ds) Antibody
Sjogren's Antibodies (SS-A, SS-B)
Sm Antibody
RNP Antibody
Chromatin (Nucleosomal) Antibody
Complement Component C3c and C4c
Complement, Total (CH50)

If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).

Methodology

See individual tests

Reference Range(s)

See Laboratory Report

Alternative Name(s)

Systemic Lupus Erythematosus (SLE),FANA,Antinuclear Antibody Screen,Fluorescent ANA,Hep-2,Progressive ANA

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

1 mL serum collected in each of 4 separate tubes

Minimum Volume

0.5 mL serum collected in each of 4 separate tubes

Transport Container

Transport tubes (x4)

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 7 days

Reject Criteria

Gross hemolysis • Lipemia • Received thawed • Microbial contamination may interfere • Grossly icteric

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

1 mL serum collected in each of 4 separate tubes

Minimum Volume

0.5 mL serum collected in each of 4 separate tubes

Transport Container

Transport tubes (x4)

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 7 days

Reject Criteria

Gross hemolysis • Lipemia • Received thawed • Microbial contamination may interfere • Grossly icteric

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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