Mixed Connective Tissue Disease Panel (RNP Antibody and ANA with Reflex)

Test Code

19875

CPT Code(s)

86038, 86235

Test Code

19875

CPT Code(s)

86038, 86235

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Mixed Connective Tissue Disease Panel (RNP Antibody and ANA with Reflex) -

This panel can be helpful in the diagnosis of individuals with clinical suspicion of mixed connective tissue disease (MCTD). All specimens are tested for antinuclear antibodies (ANAs) with an immunofluorescence assay (IFA), performed on human epithelial type 2 (HEp-2) cells; and RNP antibodies with a multiplex immunoassay. For specimens with positive ANA IFA results, reflex testing for ANA titer and pattern is performed.

The laboratory evaluation for individuals with clinical suspicion of autoimmune diseases often begins with an ANA screen. The classic ANA IFA on HEp-2 cells is considered ...

Test Resources

Clinical Focus

Autoimmune Rheumatic and Related Diseases

Test Details

Includes

ANA Screen, IFA, with Reflex to Titer and Pattern
RNP Antibody
If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).

Methodology

Immunoassay (IA) • Immunofluorescence Assay (IFA)

Reference Range(s)

See individual tests

Alternative Name(s)

Ribonucleoprotein,Mixed Connective Tissue Disease,MCTD,FANA,Antinuclear Antibody Screen,Fluorescent ANA,Hep-2,Progressive ANA

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

ANA Screen, IFA, with Reflex to Titer and Pattern
RNP Antibody

If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).

Methodology

Immunoassay (IA) • Immunofluorescence Assay (IFA)

Reference Range(s)

See individual tests

Alternative Name(s)

Ribonucleoprotein,Mixed Connective Tissue Disease,MCTD,FANA,Antinuclear Antibody Screen,Fluorescent ANA,Hep-2,Progressive ANA

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

2 mL serum

Minimum Volume

1 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria

Gross hemolysis • Grossly lipemic • Grossly icteric • Microbial contamination may interfere

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

2 mL serum

Minimum Volume

1 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria

Gross hemolysis • Grossly lipemic • Grossly icteric • Microbial contamination may interfere

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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