von Willebrand Disease Panel without Collagen Binding Assay (CBA)

von Willebrand Disease Panel without Collagen Binding Assay (CBA)

Test Code

19790
85240, 85245, 85246, 85247, 85730
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
19790
85240, 85245, 85246, 85247, 85730
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

von Willebrand Disease Panel without Collagen Binding Assay (CBA) -

This panel may be used to help diagnose von Willebrand disease (VWD) and categorize disease subtype.

von Willebrand factor (VWF) is a blood coagulation protein that has 2 functions: (1) mediating platelet adhesion to the injured endothelium and (2) acting as a protective carrier protein for coagulation factor VIII. Deficiency of VWF causes VWD, the most common inherited bleeding disorder that affects approximately 1 in 1,000 individuals at the primary care level [1]. VWD is classified into type 1 (quantitative deficiency of VWF), type 2 (qualitative deficiency of VWF), and type 3 (total ...

Test Resources

Test FAQ

von Willebrand Comprehensive Panel

Test Details

Includes

  • Partial Thromboplastin Time, Activated
  • Factor VIII Activity, Clotting
  • Ristocetin Cofactor
  • von Willebrand Factor Antigen
  • von Willebrand Antigen Multimeric Analysis

Methodology

See individual tests

Assay Category

von Willebrand Antigen, Multimeric Analysis: This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See individual tests

Alternative Name(s)

vWF, VWD

LOINC® Codes, Performing Laboratory

Service Area must be determined
Partial Thromboplastin Time, Activated
Factor VIII Activity, Clotting
Ristocetin Cofactor
von Willebrand Factor Antigen
von Willebrand Antigen Multimeric Analysis

Methodology

See individual tests
von Willebrand Antigen, Multimeric Analysis: This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See individual tests

Alternative Name(s)

vWF, VWD
Service Area must be determined

Preferred Specimen(s)

1 mL (x4) frozen platelet-poor plasma collected in 3.2% sodium citrate (light blue-top) tubes

Minimum Volume

0.75 mL (x4)

Collection Instructions

Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice.

Note: Storage of whole blood at refrigerated temperatures prior to processing may lead to cryoprecipitate formation and falsely low Factor ViII and von Willebrand Factor studies.

Transport Container

Transport tube(s)

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: Unacceptable
  • Refrigerated: Unacceptable
  • Frozen: 14 days

Reject Criteria

Received room temperature • Received refrigerated

Setup Schedule

Service Area must be determined
1 mL (x4) frozen platelet-poor plasma collected in 3.2% sodium citrate (light blue-top) tubes

0.75 mL (x4)

Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice.

Note: Storage of whole blood at refrigerated temperatures prior to processing may lead to cryoprecipitate formation and falsely low Factor ViII and von Willebrand Factor studies.

Transport tube(s)
Frozen
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 14 days
Received room temperature • Received refrigerated
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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