Thyroid Transcription Factor-1 (TTF-1), IHC with Interpretation

Test Code

19278

CPT Code(s)

88342

Test Code

19278

CPT Code(s)

88342

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Thyroid Transcription Factor-1 (TTF-1), IHC with Interpretation -

This immunoassay is often used to evaluate neoplasms of unknown origin and assist in characterizing whether the neoplasm was derived from a pulmonary or thyroid lineage [1].

Thyroid transcription factor 1 (TTF-1) is a nuclear protein that is expressed in certain lung, thyroid, and diencephalon cells. Papillary, follicular, and medullary thyroid carcinomas are generally immunoreactive with TTF-1 antibodies. Approximately 75% of nonmucinous primary pulmonary adenocarcinomas and 90% of primary pulmonary small cell carcinomas are immunoreactive with TTF-1 antibodies. Primary pulmonary squamous ...

Test Resources

Topic Brief

Non-Small Cell Lung Cancer (NSCLC): Laboratory Support of Diagnosis and Management

Test Details

Methodology

Immunohistochemistry

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Immunohistochemistry

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

Formalin-fixed paraffin embedded tissue

Alternative Specimen(s)

Unstained charged(+) slides

Minimum Volume

3 unstained, positively charged slides, submitted in IHC specimen transport kit

Transport Container

IHC specimen transport kit

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Reject Criteria

Received frozen • Specimens other than paraffin block or slides

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

Formalin-fixed paraffin embedded tissue

Alternative Specimen(s)

Unstained charged(+) slides

Minimum Volume

3 unstained, positively charged slides, submitted in IHC specimen transport kit

Transport Container

IHC specimen transport kit

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Reject Criteria

Received frozen • Specimens other than paraffin block or slides

Setup Schedule

Service Area must be determined

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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