Oxycodone and Metabolite, Quantitative

Oxycodone and Metabolite, Quantitative

Test Code

18885
80299
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
18885
80299
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Oxycodone and Metabolite, Quantitative - For therapeutic drug monitoring of oxycodone (Oxycontin®, Percocet®, Percodan®). Oxycodone is a semisynthetic opioid analgesic. Steady state concentration is reached in 24-36 hours after initiation of therapy. Elimination half-life of oxycodone is 4.5 hours for controlled release and 3.2 hours for immediate release formulations. Peak plasma concentration of oxycodone is 11, 21, 39, 99, or 156 ng/mL after a single oral dose of 10, 20, 40, 80, or 160 mg respectively. Oxymorphone is a minor but active metabolite of oxycodone that is present at lower concentration in the circulation. Therapeutic concentrations for oxymorphone have not been established.

Test Resources

Topic Brief

Drug Half-Life, Steady State, and Recommended Sample Collection Time

Test Details

Includes

  • Oxycodone and Oxymorphone

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Oxycodone 10-100 ng/mL
Oxymorphone
Peak plasma concentrations 1 hour after a single immediate-release tablet containing 5 mg of Oxycodone: 9-38 ng/mL.
Peak plasma concentrations within 2.5 hours after 10 mg of immediate-release preparation of Oxycodone: 13-46 ng/mL.
Mean peak plasma concentrations following a single dose of a 40 to 80 mg controlled-release Oxycodone preparation: 39-100 ng/mL.
Toxicity may be significant at greater than 200 ng/mL.
However, concentrations associated with toxicity are variable and depend on an individual's tolerance to the drug.

Alternative Name(s)

Percocet®

LOINC® Codes, Performing Laboratory

Service Area must be determined
Oxycodone and Oxymorphone

Methodology

Chromatography/Mass Spectrometry
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Oxycodone 10-100 ng/mL
Oxymorphone
Peak plasma concentrations 1 hour after a single immediate-release tablet containing 5 mg of Oxycodone: 9-38 ng/mL.
Peak plasma concentrations within 2.5 hours after 10 mg of immediate-release preparation of Oxycodone: 13-46 ng/mL.
Mean peak plasma concentrations following a single dose of a 40 to 80 mg controlled-release Oxycodone preparation: 39-100 ng/mL.
Toxicity may be significant at greater than 200 ng/mL.
However, concentrations associated with toxicity are variable and depend on an individual's tolerance to the drug.

Alternative Name(s)

Percocet®
Service Area must be determined

Preferred Specimen(s)

5 mL serum collected in a red-top tube (no gel)

Minimum Volume

3 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 7 days
  • Refrigerated: 7 days
  • Frozen: 7 days

Reject Criteria

Serum separator tube (SST)

Setup Schedule

Service Area must be determined
5 mL serum collected in a red-top tube (no gel)
3 mL
Transport tube
Room temperature
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 7 days
Serum separator tube (SST)
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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