IgE Antibody (Anti-IgE IgG)

Test code

18877

CPT code(s)*

83520

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide Service Area Information to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical significance

IgE Antibody (Anti-IgE IgG) - Chronic urticaria is a common skin disorder affecting 1 to 6% of the general population. It is characterized by repeated occurrence of short-lived cutaneous wheals accompanied by redness and itching. Autoimmune urticaria is defined by the presence of a functional IgG antibody to high-affinity IgE receptor (Fc epsilon RI alpha) or to IgE. These antibodies trigger mast cell and basophil degranulation by the engagement of Fc epsilon receptor. Functional IgG antibody to the receptor has been identified in approximately 30-40% of patients with chronic urticaria, and anti-IgE antibody has been identified in another 5% to 10%. The anti-IgE assay will quantify…

Test resources

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Details

Test details

Methodology

Immunoassay (IA)

Assay category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Alternative name(s)

Chronic Urticaria

Specimen requirements
Patient preparation	Overnight fasting is preferred
Preferred specimen(s)	0.5 mL serum collected in a red-top tube (no gel)
Minimum volume	0.3 mL
Collection instructions	Serum should be separated from the cells as soon as possible after visible clot formation (usually 15-30 minutes after collection)
Transport container	Transport tube
Transport temperature	Room temperature
Specimen stability	Room temperature: 7 days Refrigerated: 7 days Frozen: 28 days
Reject criteria	Moderate or gross hemolysis • Grossly lipemic • Grossly icteric • Serum separator tube (SST)

Reference range(s)

<168 ng/mL

LOINC® codes

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Service Area Information

Performing lab & setup schedule

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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