Aldosterone/Cortisol Ratio, Adrenal Vein Sampling, 7 Sites

Test code

18827

CPT code(s)*

82088 (x7), 82533 (x7)

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Clinical significance

Aldosterone/Cortisol Ratio, Adrenal Vein Sampling, 7 Sites - Measurements of aldosterone/cortisol ratios in samples of adrenal venous blood, obtained by an experienced radiologist, is the "gold standard" test to distinguish between an adenoma or unilateral hyperplasia and bilateral hyperplasia. Unilateral disease is associated with a marked (usually greater than four-fold) increase in Aldosterone/Cortisol on the side of the tumor, whereas there is little difference between the two sides in patients with bilateral hyperplasia. AVS with Aldosterone/Cortisol measurement is indicated if imaging studies fail to unequivocally identify an adenoma or if the identified adenoma is <1 cm in size.

Test resources

None found for this test
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Details

Test details

Includes

Aldosterone
Cortisol, Total
Aldosterone/Cortisol Ratio

Methodology

Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)

Assay category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Specimen requirements
Patient preparation	None Specified
Preferred specimen(s)	2 mL serum collected in each of seven red-top tubes (no gel)
Alternative specimen(s)	Plasma collected in each of seven EDTA (lavender-top) tubes
Minimum volume	0.5 mL (x7)
Collection instructions	For each timed specimen submitted, each tube must be clearly marked with time drawn and the exact location of the sample collection. Submit all tubes with one test requisition.
Transport container	Transport tube (x7)
Transport temperature	Frozen
Specimen stability	Room temperature: 4 days Refrigerated: 7 days Frozen: 28 days
Reject criteria	Moderate to gross hemolysis • Serum separator tubes (SST)

Reference range(s)

See Laboratory Report

LOINC® codes

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Service Area Information

Performing lab & setup schedule

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Service Area Information

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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