logo

Pediatric Autoimmune Encephalitis Evaluation with Reflexes, CSF

Test code

18420

CPT code(s)*

86052, 84182, 86362, 86341, 86255
Notices
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide Service Area Information to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical significance

Pediatric Autoimmune Encephalitis Evaluation with Reflexes, CSF - Causes of autoimmune encephalitis differ between adults and children, largely due to the fact that autoimmune encephalitis in adults is more likely to be due to cancer, but in children more likely to have been caused by a viral infection. This panel will assess the most common causes of autoimmune encephalitis/encephalomyelitis in the pediatric age group.
Show more

Test resources

Algorithm

Suggested Use of Pediatric Autoimmune Encephalitis Panels in the Diagnosis of Autoimmune Encephalitis

Test summary

Pediatric Encephalitis With Reflexes, Serum and CSF

Details

Test details

Includes

Aquaporin-4 (AQP4) Antibody, CBA with Reflex to Titer, CSF
Collapsin Response-Mediator Protein-5 (CRMP5/CV2) Antibody, Line Blot, CSF
Glutamic Acid Decarboxylase (GAD65) Antibody, Line Blot, CSF
MOG Antibody, CBA with Reflex to Titer, CSF
NMDAR1 Antibody, CBA with Reflex to Titer, CSF

If Aquaporin-4 (AQP4) Antibody, CBA is Positive, then Aquaporin-4 (AQP4) Antibody, Titer will be performed at an additional charge (CPT Code(s): 86052).

If MOG Antibody, CBA is Positive, then MOG Antibody, Titer will be performed at an additional charge (CPT Code(s): 86362).

If NMDAR1 Antibody, CBA is Positive, then NMDAR1 Antibody, Titer will be performed at an additional charge (CPT Code(s): 86256).

Methodology

Cell-based Immunofluorescence Assay • Line Blot

Specimen requirements
Patient preparationNone Specified
Preferred specimen(s)2 mL CSF collected in a plastic screw-cap vial
Minimum volume1.2 mL
Transport containerPlastic screw-cap vial
Transport temperatureRoom temperature
Specimen stabilityRoom temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days
Reject criteriaVisible particulate matter
Service Area Information

AQP4 Ab, CBANegative
CRMP5 (CV2) Ab, LB<11 SI
GAD65 Ab, LB<11 SI
MOG Ab, CBANegative
NMDAR1 Ab, CBANegative
   
   AQP4 Ab, Titer<1:2
   MOG Ab, Titer<1:2
   NMDAR1 Ab, Titer<1:2

Service Area Information
Service Area Information

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.

Quest, Quest Diagnostics, the associated logo, Nichols Institute and all associated Quest Diagnostics marks are the registered trademarks of Quest Diagnostics. All third party marks— ® and ™ — are the property of their respective owners. © 2000-2019 Quest Diagnostics Incorporated. All rights reserved.