Protein S Activity

Test Code

1779

CPT Code(s)

85306

Test Code

1779

CPT Code(s)

85306

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Protein S Activity - Protein S (PS) deficiency may be congenital or acquired and is associated with venous thrombosis. Acquired PS deficiency may occur with vitamin K antagonists/deficiency, liver disease, malignancy, consumptive DIC, surgery, trauma, and hepatic immaturity of the newborn. In addition, PS deficiency is physiologic in pregnancy.

Anticoagulant interference: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Vitamin K Antagonists (eg. warfarin):
decrease; Heparin (UFH or LMWH): no effect to falsely increased activity levels at higher levels; Dabigatran ...

Test Resources

None found for this test
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Test Details

Methodology

Clot Detection

Reference Range(s)

Male	70-150 % normal
Female	60-140 % normal

Alternative Name(s)

Protein S, Functional

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Clot Detection

Reference Range(s)

Male	70-150 % normal
Female	60-140 % normal

Alternative Name(s)

Protein S, Functional

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

1 mL frozen plasma collected in 3.2% sodium citrate (light blue-top) tube

Minimum Volume

0.5 mL

Collection Instructions

Centrifuge light blue-top tube for 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/uL). Freeze immediately and ship on dry ice.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days

Reject Criteria

Hemolysis • Received thawed

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

1 mL frozen plasma collected in 3.2% sodium citrate (light blue-top) tube

Minimum Volume

0.5 mL

Collection Instructions

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days

Reject Criteria

Hemolysis • Received thawed

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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