Chronic Lymphocytic Leukemia (CLL) Prognostic Panel without Karyotype

Test Code

17312

CPT Code(s)

81263, 82232, 88184, 88185 (x2), 88271 (x6), 88275 (x3)

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

17312

CPT Code(s)

81263, 82232, 88184, 88185 (x2), 88271 (x6), 88275 (x3)

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Chronic Lymphocytic Leukemia (CLL) Prognostic Panel without Karyotype - Chronic Lymphocytic leukemia is the most common leukemia in the Western world. The disease is chronic and most patients may not require therapy in the early stage of the disease. However, in some patients the disease can be aggressive and within a year the tumor mass may increase significantly imposing serious health problems to the patient. It is difficult to determine based on clinical presentation which patient will progress faster than the others. Therefore, there is a need to use more accurate prognostic indicator to predict the clinical course of this disease. The recent advances in CLL therapy ...

Test Resources

None found for this test
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Test Details

Includes

Beta-2 Microglobulin, Serum
Chronic Lymphocytic Leukemia, IgVH Mutation Status
CD38+/CD19+
FISH, B-Cell Chronic Lymphocytic Leukemia Panel
ZAP-70

Methodology

Flow Cytometry (FC) • Fluorescence in situ Hybridization (FISH) • Immunoturbidometric • Next Generation Sequencing (NGS) • Sequencing

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

Beta-2 Microglobulin, Serum
Chronic Lymphocytic Leukemia, IgVH Mutation Status
CD38+/CD19+
FISH, B-Cell Chronic Lymphocytic Leukemia Panel
ZAP-70

Methodology

Flow Cytometry (FC) • Fluorescence in situ Hybridization (FISH) • Immunoturbidometric • Next Generation Sequencing (NGS) • Sequencing

Assay Category

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

5 mL whole blood collected in an EDTA (lavender-top) tube and
16 mL whole blood collected in a sodium heparin (green-top) tube and
1 mL serum

Minimum Volume

3 mL EDTA whole blood • 10 mL sodium heparin whole blood • 0.5 mL serum

Collection Instructions

See individual tests

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable

Reject Criteria

Hemolysis • Lipemia

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

5 mL whole blood collected in an EDTA (lavender-top) tube and
16 mL whole blood collected in a sodium heparin (green-top) tube and
1 mL serum

Minimum Volume

3 mL EDTA whole blood • 10 mL sodium heparin whole blood • 0.5 mL serum

Collection Instructions

See individual tests

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable

Reject Criteria

Hemolysis • Lipemia

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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