Aldosterone, LC/MS/MS

Test Code

17181

CPT Code(s)

82088

Test Code

17181

CPT Code(s)

82088

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Aldosterone, LC/MS/MS - Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body positions, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.

Test Resources

Algorithm

Interpretation of Plasma Renin Activity With Reflex to Aldosterone Test (test code 13817)

Test Summary

Plasma Renin Activity With Reflex to Aldosterone

Test Details

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Adult
Upright 8:00-10:00 am	≤28 ng/dL
Upright 4:00-6:00 pm	≤21 ng/dL
Supine 8:00-10:00 am	3-16 ng/dL
Pediatric
1-12 months**	2-70 ng/dL
1-4 years**	2-37 ng/dL
5-9 years	≤9 ng/dL
10-13 years	≤21 ng/dL
14-17 years	≤35 ng/dL
Infants
Premature (31-35 weeks)**	≤144 ng/dL
Term**	≤217 ng/dL
Tanner Stages**
II-III Males	1-13 ng/dL
II-III Females	2-20 ng/dL
IV-V Males	3-14 ng/dL
IV-V Females	4-32 ng/dL

**Pediatric data from J Clin Endocrinol Metab. 1992;75:1491 and J CLin Endocrinol Metab. 1989; 69;1133-1136.

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Chromatography/Mass Spectrometry

Assay Category

Reference Range(s)

Adult
Upright 8:00-10:00 am	≤28 ng/dL
Upright 4:00-6:00 pm	≤21 ng/dL
Supine 8:00-10:00 am	3-16 ng/dL
Pediatric
1-12 months**	2-70 ng/dL
1-4 years**	2-37 ng/dL
5-9 years	≤9 ng/dL
10-13 years	≤21 ng/dL
14-17 years	≤35 ng/dL
Infants
Premature (31-35 weeks)**	≤144 ng/dL
Term**	≤217 ng/dL
Tanner Stages**
II-III Males	1-13 ng/dL
II-III Females	2-20 ng/dL
IV-V Males	3-14 ng/dL
IV-V Females	4-32 ng/dL

**Pediatric data from J Clin Endocrinol Metab. 1992;75:1491 and J CLin Endocrinol Metab. 1989; 69;1133-1136.

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

1 mL serum collected in a red-top tube (no gel)

Alternative Specimen(s)

Plasma collected in: EDTA (lavender-top), sodium heparin (green-top), or lithium heparin (green-top)

Minimum Volume

0.25 mL

Collection Instructions

Separate serum after clotting. Do not submit glass tubes.
Draw "upright" samples at least 1/2 hour after patient sits up.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria

Moderate to gross hemolysis • Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

1 mL serum collected in a red-top tube (no gel)

Alternative Specimen(s)

Plasma collected in: EDTA (lavender-top), sodium heparin (green-top), or lithium heparin (green-top)

Minimum Volume

0.25 mL

Collection Instructions

Separate serum after clotting. Do not submit glass tubes.
Draw "upright" samples at least 1/2 hour after patient sits up.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria

Moderate to gross hemolysis • Serum separator tube (SST)

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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