Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS

Test Code

16845

CPT Code(s)

82088, 84244

Test Code

16845

CPT Code(s)

82088, 84244

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS - The Aldosterone-renin ratio is used to screen for primary aldosteronism.

Test Resources

Algorithm

Interpretation of Plasma Renin Activity With Reflex to Aldosterone Test (test code 13817)

Test Summary

Plasma Renin Activity With Reflex to Aldosterone

Test Details

Includes

Aldosterone, LC/MS and Plasma Renin Activity, LC/MS/MS

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Aldosterone

Adult
Upright 8:00-10:00 A.M.	≤28 ng/dL
Upright 4:00-6:00 P.M.	≤21 ng/dL
Supine 8:00-10:00 A.M.	3-16 ng/dL
Pediatric
1-12 Months	2-70 ng/dL
1-4 Years	2-37 ng/dL
5-9 Years	≤9 ng/dL
10-13 Years	≤21 ng/dL
14-17 Years	≤35 ng/dL
Infants
Premature (31-35 Weeks)	≤144 ng/dL
Term	≤217 ng/dL
Tanner Stages
II-III Males	1-13 ng/dL
II-III Females	2-20 ng/dL
IV-V Males	3-14 ng/dL
IV-V Females	4-32 ng/dL

Plasma Renin Activity	0.25-5.82 ng/mL/h
Aldosterone/PRA Ratio	0.9-28.9 Ratio

Alternative Name(s)

Plasma Renin Activity, LC-MS/MS,

ALDO/PRA Ratio

, PRA, Primary Aldosteronism, Aldosterone, LC-MS/MS

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

Aldosterone, LC/MS and Plasma Renin Activity, LC/MS/MS

Methodology

Chromatography/Mass Spectrometry

Assay Category

Reference Range(s)

Aldosterone

Adult
Upright 8:00-10:00 A.M.	≤28 ng/dL
Upright 4:00-6:00 P.M.	≤21 ng/dL
Supine 8:00-10:00 A.M.	3-16 ng/dL
Pediatric
1-12 Months	2-70 ng/dL
1-4 Years	2-37 ng/dL
5-9 Years	≤9 ng/dL
10-13 Years	≤21 ng/dL
14-17 Years	≤35 ng/dL
Infants
Premature (31-35 Weeks)	≤144 ng/dL
Term	≤217 ng/dL
Tanner Stages
II-III Males	1-13 ng/dL
II-III Females	2-20 ng/dL
IV-V Males	3-14 ng/dL
IV-V Females	4-32 ng/dL

Plasma Renin Activity	0.25-5.82 ng/mL/h
Aldosterone/PRA Ratio	0.9-28.9 Ratio

Alternative Name(s)

Plasma Renin Activity, LC-MS/MS,

ALDO/PRA Ratio

, PRA, Primary Aldosteronism, Aldosterone, LC-MS/MS

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

1.8 mL frozen plasma collected in an EDTA (lavender-top) tube

Minimum Volume

0.8 mL

Collection Instructions

Collect a mid-morning blood sample after patient has been upright (sitting, standing, or walking) for a minimum of 2 hours, then have them sit 5-15 minutes prior to collection.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: 24 hours
Refrigerated: 24 hours
Frozen: 28 days

Reject Criteria

Moderate to gross hemolysis • Plasma collected in a plasma separator tube • Received thawed

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

1.8 mL frozen plasma collected in an EDTA (lavender-top) tube

Minimum Volume

0.8 mL

Collection Instructions

Collect a mid-morning blood sample after patient has been upright (sitting, standing, or walking) for a minimum of 2 hours, then have them sit 5-15 minutes prior to collection.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: 24 hours
Refrigerated: 24 hours
Frozen: 28 days

Reject Criteria

Moderate to gross hemolysis • Plasma collected in a plasma separator tube • Received thawed

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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