Inflammatory Bowel Disease Differentiation Panel

Test Code

16503

CPT Code(s)

86021 (x2), 86036, 86671 (x2)

Test Code

16503

CPT Code(s)

86021 (x2), 86036, 86671 (x2)

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Inflammatory Bowel Disease Differentiation Panel - This panel is useful in the diagnosis of Inflammatory Bowel diseases and can help to distinguish patients with ulcerative colitis from those with Crohn's Disease.

Test Resources

Algorithm

Differential Diagnosis of Inflammatory Bowel Disease

Clinical Focus

Inflammatory Bowel Disease: Laboratory Support for Diagnosis and Management

Test Details

Includes

ANCA Screen with Reflex to ANCA Titer
Myeloperoxidase Antibody (MPO)
Proteinase-3 Antibody
Saccharomyces cerevisiae Antibodies (ASCA) (IgG)
Saccharomyces cerevisiae Antibodies (ASCA) (IgA)
If ANCA Screen is positive, then C-ANCA Titer and/or P-ANCA Titer, and/or atypical P-ANCA Titer will be performed at an additional charge (CPT code(s): 86037 for each titer performed).

Methodology

Immunoassay (IA)

Reference Range(s)

ANCA Screen	Negative
P-ANCA Titer	<1:20
C-ANCA Titer	<1:20
Atypical P-ANCA Titer	<1:20

Myeloperoxidase Antibody

<1.0 AI	No antibody detected
≥1.0 AI	Antibody detected

Proteinase-3 Antibody

<1.0 AI	No antibody detected
≥1.0 AI	Antibody detected

Saccharomyces cerevisiae Ab (IgG)

≤20.0 U	Negative
20.1-29.9 U	Equivocal
≥30.0 U	Positive

Saccharomyces cerevisiae Ab (IgA)

≤20.0 U	Negative
20.1-24.9 U	Equivocal
≥25.0 U	Positive

Alternative Name(s)

UC,IBD,Ulcerative Colitis,CD,Crohn's Disease

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

ANCA Screen with Reflex to ANCA Titer
Myeloperoxidase Antibody (MPO)
Proteinase-3 Antibody
Saccharomyces cerevisiae Antibodies (ASCA) (IgG)
Saccharomyces cerevisiae Antibodies (ASCA) (IgA)

If ANCA Screen is positive, then C-ANCA Titer and/or P-ANCA Titer, and/or atypical P-ANCA Titer will be performed at an additional charge (CPT code(s): 86037 for each titer performed).

Methodology

Immunoassay (IA)

Reference Range(s)

ANCA Screen	Negative
P-ANCA Titer	<1:20
C-ANCA Titer	<1:20
Atypical P-ANCA Titer	<1:20

Myeloperoxidase Antibody

<1.0 AI	No antibody detected
≥1.0 AI	Antibody detected

Proteinase-3 Antibody

<1.0 AI	No antibody detected
≥1.0 AI	Antibody detected

Saccharomyces cerevisiae Ab (IgG)

≤20.0 U	Negative
20.1-29.9 U	Equivocal
≥30.0 U	Positive

Saccharomyces cerevisiae Ab (IgA)

≤20.0 U	Negative
20.1-24.9 U	Equivocal
≥25.0 U	Positive

Alternative Name(s)

UC,IBD,Ulcerative Colitis,CD,Crohn's Disease

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

2 mL serum

Minimum Volume

1.4 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria

Gross hemolysis • Lipemia • Grossly icteric

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

2 mL serum

Minimum Volume

1.4 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria

Gross hemolysis • Lipemia • Grossly icteric

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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