HE4, Ovarian Cancer Monitoring

HE4, Ovarian Cancer Monitoring

Test Code

16500
86305
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
16500
86305
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

HE4, Ovarian Cancer Monitoring - The percentage increase in HE4 values has been used as an aid in monitoring recurrence or progressive disease in patients with invasive epithelial ovarian cancer. Currently there is no clinically accepted cut-off for use in monitoring cancer progression in epithelial ovarian cancer subjects with this assay. Serial testing for patient HE4 assay values should be used in conjunction with methods used for monitoring ovarian cancer.

Test Resources

None found for this test
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Test Details

Methodology

Chemiluminescent Microparticle Immunoassay (CMIA)

Reference Range(s)

Female Premenopausal≤70 pmol/L
Female Postmenopausal≤140 pmol/L

Alternative Name(s)

Human Epididymis Protein 4

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Chemiluminescent Microparticle Immunoassay (CMIA)

Reference Range(s)

Female Premenopausal≤70 pmol/L
Female Postmenopausal≤140 pmol/L

Alternative Name(s)

Human Epididymis Protein 4
Service Area must be determined

Preferred Specimen(s)

0.5 mL serum

Alternative Specimen(s)

SST

Minimum Volume

0.3 mL

Collection Instructions

Sample collected in a red-top tube must be allowed to clot for at least 30 minutes but no longer than 1 hour

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: 48 hours
  • Refrigerated: 72 hours
  • Frozen: 28 days

Reject Criteria

Gross hemolysis • Lipemia • Icteric specimens • Presence of fibrin, RBCs or other particulate matter • Obvious microbial contamination

Setup Schedule

Service Area must be determined
0.5 mL serum
SST
0.3 mL
Sample collected in a red-top tube must be allowed to clot for at least 30 minutes but no longer than 1 hour
Transport tube
Frozen
Room temperature: 48 hours
Refrigerated: 72 hours
Frozen: 28 days
Gross hemolysis • Lipemia • Icteric specimens • Presence of fibrin, RBCs or other particulate matter • Obvious microbial contamination
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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