Chronic Urticaria Panel 1

Chronic Urticaria Panel 1

Test Code

16440
84443, 86343, 86376, 86800
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
16440
84443, 86343, 86376, 86800
CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Chronic Urticaria Panel 1 - Chronic urticaria is a common skin disorder affecting 1% to 6% of the general population. It is characterized by repeated occurrence of short-lived cutaneous wheals accompanied by redness and itching. Autoimmune urticaria is defined by the presence of a functional IgG antibody to high-affinity IgE receptor (Fc epsilon RI alpha) or to IgE. These antibodies trigger mast cell and basophile degranulation by the engagement of Fc epsilon receptor. Functional IgG antibody to the receptor has been identified in approximately 30-40% of patients with chronic urticaria, and anti IgE antibody has been identified in another 5-10%.

Test Resources

None found for this test
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Test Details

Includes

  • Histamine Release (Chronic Urticaria)
  • Thyroid Peroxidase Antibodies (TPO)
  • Thyroglobulin Antibody
  • TSH

Patient Preparation

Patients taking calcineurin inhibitors should stop their medication for 72 hours prior to draw.

Specimen collection after fluorescein dye angiography should be delayed for at least 3 days. For patients on hemodialysis, specimen collection should be delayed for 2 weeks after angiography. According to the assay manufacturer Siemens: samples containing fluorescein can produce falsely depressed values.

Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Methodology

See individual tests

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See individual tests

LOINC® Codes, Performing Laboratory

Service Area must be determined
Histamine Release (Chronic Urticaria)
Thyroid Peroxidase Antibodies (TPO)
Thyroglobulin Antibody
TSH
Patients taking calcineurin inhibitors should stop their medication for 72 hours prior to draw.

Specimen collection after fluorescein dye angiography should be delayed for at least 3 days. For patients on hemodialysis, specimen collection should be delayed for 2 weeks after angiography. According to the assay manufacturer Siemens: samples containing fluorescein can produce falsely depressed values.

Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Methodology

See individual tests
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See individual tests
Service Area must be determined

Preferred Specimen(s)

5.4 mL serum collected in a red-top tube (no gel)

Minimum Volume

2.7 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

  • Room Temperature: 7 days
    Refrigerated: 7 days
    Frozen: 28 days

Reject Criteria

Gross hemolysis • Lipemia • Icteric specimen • Specimen other than serum • Serum separator tube (SST)

Setup Schedule

Service Area must be determined
5.4 mL serum collected in a red-top tube (no gel)
2.7 mL
Transport tube
Room temperature
Room Temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Gross hemolysis • Lipemia • Icteric specimen • Specimen other than serum • Serum separator tube (SST)
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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