Celiac Disease Comprehensive Panel, Infant
Test Code
Clinical Significance
Celiac Disease Comprehensive Panel, Infant - Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.
Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.
Test Resources
Test Details
IgA (Immunoglobulin A)
Gliadin (Deamidated) Antibody (IgA)
If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86231).
If the Endomysial Antibody Screen (IgA) is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).
If Immunoglobulin A is less than the lower limit of the reference range, based on age, then Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364).
Methodology
Reference Range(s)
| <15.0 U/mL | Antibody not detected | |
| ≥15.0 U/mL | Antibody detected | |
Gliadin (Deamidated) Antibody (IgA)
| <15.0 U/mL | Antibody not detected | |
| ≥15.0 U/mL | Antibody detected | |
IgA (Immunoglobulin A)
| Cord Blood | Not Established |
| ≤3 months | 5-40 mg/dL |
| 4-6 months | 7-47 mg/dL |
| 7-11 months | 12-53 mg/dL |
| 1 year | 20-73 mg/dL |
| 2 years | 20-99 mg/dL |
| 3-5 years | 22-140 mg/dL |
| 6-8 years | 31-180 mg/dL |
| 9-11 years | 33-200 mg/dL |
| 12-16 years | 36-220 mg/dL |
| 17-60 years | 47-310 mg/dL |
| ≥61 years | 70-320 mg/dL |
Alternative Name(s)
Preferred Specimen(s)
5 mL serum
Note: Specimens from children less than 4 years of age (i.e., less than 48 months) are appropriate for this test. The test for people 4 years of age and older is the Celiac Disease Comprehensive Panel (test code 19955).
Minimum Volume
1.1 mL
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 72 hours
- Refrigerated: 7 days
- Frozen: 21 days
Reject Criteria
Gross hemolysis • Grossly lipemic
Setup Schedule
Note: Specimens from children less than 4 years of age (i.e., less than 48 months) are appropriate for this test. The test for people 4 years of age and older is the Celiac Disease Comprehensive Panel (test code 19955).
Refrigerated: 7 days
Frozen: 21 days