dRVVT Screen with Reflex to dRVVT Confirm and dRVVT 1:1 Mix
Test Code
Clinical Significance
dRVVT Screen with Reflex to dRVVT Confirm and dRVVT 1:1 Mix - The dilute Russell Viper Venom time integrated test is a sensitive method for the detection of Lupus Anticoagulants (LA). LA are autoantibodies that target protein-phospholipid complexes and are found in a variety of clinical conditions. In some patients, a confirmed positive result is associated with an increased thrombotic risk, and is often found in women who have recurrent fetal loss. As Lupus anticoagulants reflect a heterogenous group of antibodies, international consensus guidelines on testing require at least two screening assays be used for a complete evaluation. Refer to Lupus Anticoagulant ...
Test Resources
Please visit our Clinical Education Center to stay informed on any future publications, webinars, or other education opportunities.
Test Details
If dRVVT Confirm is positive, then dRVVT 1:1 Mixing Study will be performed at an additional charge (CPT code(s): 85613).
Methodology
Reference Range(s)
| dRVVT Screen | ≤45 seconds |
| dRVVT Confirm | Negative |
| dRVVT 1:1 Mix | Corrected |
Alternative Name(s)
Preferred Specimen(s)
1 mL frozen platelet-poor plasma collected in a 3.2% sodium citrate (light blue-top) tube
Minimum Volume
0.5 mL
Collection Instructions
Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice.
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
- Room temperature: Unacceptable
- Refrigerated: Unacceptable
- Frozen: 90 days
Reject Criteria
Hemolysis
Setup Schedule
Refrigerated: Unacceptable
Frozen: 90 days