CAH Panel 1 (21-Hydroxylase vs 11Beta-Hydroxylase Deficiency)

CAH Panel 1 (21-Hydroxylase vs 11Beta-Hydroxylase Deficiency)

Test Code

15269
83498, 82634, 82533, 82157, 84403
15269
83498, 82634, 82533, 82157, 84403
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

CAH Panel 1 (21-Hydroxylase vs 11Beta-Hydroxylase Deficiency) - Deficiency of 21-Hydroxylase is the most frequent cause of congenital adrenal hyperplasia (accounting for ~95% of cases) and 11Beta-Hydroxylase is the second most frequent (~5% of cases). Deficiencies of these two enzymes result in the accumulation of distinct steroid precursors.

Test Resources

None found for this test
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Test Details

Includes

  • 11-Deoxycortisol
  • Cortisol, Total, LC/MS
  • 17-Hydroxyprogesterone
  • Androstenedione
  • Testosterone, Total, MS

Methodology

Chromatography/Mass Spectrometry

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See individual tests

LOINC® Codes, Performing Laboratory

Service Area must be determined
11-Deoxycortisol
Cortisol, Total, LC/MS
17-Hydroxyprogesterone
Androstenedione
Testosterone, Total, MS

Methodology

Chromatography/Mass Spectrometry

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See individual tests
Service Area must be determined

Preferred Specimen(s)

3 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.6 mL

Collection Instructions

An early morning specimen is preferred. Specify time of day specimen was collected, patient age and sex on test requisition.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 48 hours
  • Refrigerated: 7 days
  • Frozen: 28 days

Reject Criteria

Gross hemolysis • Grossly lipemic • Serum separator tube (SST)

Setup Schedule

Service Area must be determined
3 mL serum collected in a red-top tube (no gel)
0.6 mL
An early morning specimen is preferred. Specify time of day specimen was collected, patient age and sex on test requisition.
Transport tube
Refrigerated (cold packs)
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 28 days
Gross hemolysis • Grossly lipemic • Serum separator tube (SST)
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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