Actin (Smooth Muscle) Antibody (IgG)

Test Code

15043

CPT Code(s)

86015

Test Code

15043

CPT Code(s)

86015

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Actin (Smooth Muscle) Antibody (IgG) - Actin is the major antigen to which smooth muscle antibodies react in autoimmune hepatitis. F-Actin IGG antibodies are found in 52-85% of patients with Autoimmune Hepatitis (AIH) or chronic active hepatitis and in 22% of patients with Primary Biliary Cirrhosis (PBC). Anti-Actin antibodies have been reported in 3-18% of sera from normal healthy controls.

Test Resources

None found for this test
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Test Details

Methodology

Enzyme Linked Immunosorbent Immunoassay (ELISA)

Reference Range(s)

<20 U	Negative
≥20 U	Positive

Antibodies recognizing actin are the main component of smooth muscle antibodies associated with autoimmune liver disease. Actin antibodies are found in approximately 75% of patients with autoimmune hepatitis (AIH) type 1, approximately 65% of patients with autoimmune cholangitis, approximately 30% of patients with primary biliary cirrhosis, and approximately 2% of healthy people. High values are closely correlated with AIH type 1.

Alternative Name(s)

Anti-Smooth Muscle Ab IgG,ASMA IgG,F-Actin Antibody,Smooth Muscle Antibody IgG

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Enzyme Linked Immunosorbent Immunoassay (ELISA)

Reference Range(s)

<20 U	Negative
≥20 U	Positive

Alternative Name(s)

Anti-Smooth Muscle Ab IgG,ASMA IgG,F-Actin Antibody,Smooth Muscle Antibody IgG

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

0.5 mL serum

Minimum Volume

0.25 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria

Gross hemolysis • Lipemia • Microbially contaminated serum • Specimens containing heavy, visible particulate

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

0.5 mL serum

Minimum Volume

0.25 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria

Gross hemolysis • Lipemia • Microbially contaminated serum • Specimens containing heavy, visible particulate

Setup Schedule

Service Area must be determined

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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