MuSK and LRP4 Antibodies Panel

Test Code

1490

CPT Code(s)

86366, 86255

Test Code

1490

CPT Code(s)

86366, 86255

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

MuSK and LRP4 Antibodies Panel - Detects anti-MuSK (muscle specific receptor tyrosine kinase) and anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG). MuSK is a transmembrane endplate polypeptide involved in a signaling pathway that maintains the normal functional integrity of the neuromuscular junction (NMJ). The LRP4 protein activates MuSK kinase activity and promotes the clustering of the acetylcholine receptor (AChR) and its stabilization at the NMJ. Approximately 8% to 10% of all MG cases and 20% to 50% of the generalized MG cases who lack anti-AChR have anti-MuSK. ...

Test Resources

Clinical Focus

Myasthenia Gravis and Autoantibodies

Test Details

Methodology

Immunofluorescence Assay (IFA) • Radioimmunoassay (RIA)

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Immunofluorescence Assay (IFA) • Radioimmunoassay (RIA)

Reference Range(s)

See Laboratory Report

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

2 mL serum

Minimum Volume

0.5 mL

Collection Instructions

Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 25 days
Frozen: 25 days

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

2 mL serum

Minimum Volume

0.5 mL

Collection Instructions

Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 25 days
Frozen: 25 days

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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