FISH, ETV6/RUNX1 (TEL/AML1), Translocation (12;21)

FISH, ETV6/RUNX1 (TEL/AML1), Translocation (12;21)

Test Code

14618

CPT Code(s)

88271 (x2), 88275

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Test Code

14618

CPT Code(s)

88271 (x2), 88275

CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

FISH, ETV6/RUNX1 (TEL/AML1), Translocation (12;21) - This fluorescence in situ hybridization (FISH) assay detects the ETV6/RUNX1 (TEL/AML1) fusion gene and is used for determining prognosis of patients with acute lymphoblastic leukemia (ALL) and monitoring for recurrence.

The ETV6/RUNX1 (TEL/AML1) fusion gene results from the t(12;21)(p13;q22) translocation and is usually undetectable by conventional chromosome analysis [1]. Although it occurs rarely in adults, it is the most common recurrent translocation in B-lineage pediatric ALL (frequency ~25%) [2]. The presence of the ETV6/RUNX1 (TEL/AML1) fusion ...

Test Resources

None found for this test
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Test Details

Methodology

Fluorescence in situ Hybridization (FISH)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

Alternative Name(s)

TEL/AML1, T(12;21),Gene Fusion, FISH,ETV6/RUNX1 T(12;21),Cryptic Translocation,ALL,TEL/AML1,Acute Lymphoblastic Leukemia (ALL)

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Fluorescence in situ Hybridization (FISH)

Assay Category

Reference Range(s)

See Laboratory Report

Alternative Name(s)

TEL/AML1, T(12;21),Gene Fusion, FISH,ETV6/RUNX1 T(12;21),Cryptic Translocation,ALL,TEL/AML1,Acute Lymphoblastic Leukemia (ALL)

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

5 mL whole blood or 3 mL bone marrow collected in a sodium heparin (green-top) tube

Alternative Specimen(s)

Sodium heparin (royal blue-top) tube • Sodium heparin lead-free (tan-top) tube

Minimum Volume

1 mL

Transport Container

Sodium heparin (green-top) tube

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

5 mL whole blood or 3 mL bone marrow collected in a sodium heparin (green-top) tube

Alternative Specimen(s)

Sodium heparin (royal blue-top) tube • Sodium heparin lead-free (tan-top) tube

Minimum Volume

1 mL

Transport Container

Sodium heparin (green-top) tube

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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